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- Publisher Website: 10.1016/j.scib.2021.01.026
- Scopus: eid_2-s2.0-85102854228
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Article: LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia
Title | LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia |
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Authors | |
Keywords | Influenza A virus LIGHT/TNFSF14 Natural killer T cells Alveolar macrophages |
Issue Date | 2021 |
Publisher | Elsevier B.V. and Science China Press. The Journal's web site is located at http://www.sciencedirect.com/science/journal/20959273?sdc=1 |
Citation | Science Bulletin, 2021, Epub 2021-01-26 How to Cite? |
Abstract | CD1d-restricted natural killer T (NKT) cells are innate-like T lymphocytes with protective or pathogenic roles in the development of influenza pneumonia. Here, we show that lung-infiltrated and activated NKT cells are the major cellular source of LIGHT/TNFSF14, which determines the severity of pulmonary pneumonia by highly deteriorative influenza A virus (IAV) infection. Compared to wild-type mice, LIGHT−/− mice exhibit much lower morbidity and mortality to IAV, due to alleviated lung damage and reduced apoptosis of alveolar macrophages (AMs). LIGHT preferentially promotes cell death of lymphotoxin β receptors positive (LTβR+) AMs but not herpesvirus entry mediator positive (HVEM+) AMs. Therefore, these results suggest that NKT-derived LIGHT augments cell death of the tissue protective AMs in exacerbating lung pathology and susceptibility to fatal influenza infection. Suppression of LIGHT signaling might be a viable option in the treatment of influenza-associated acute respiratory distress syndrome. |
Persistent Identifier | http://hdl.handle.net/10722/299774 |
ISSN | 2023 Impact Factor: 18.8 2023 SCImago Journal Rankings: 2.807 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shi, LN | - |
dc.contributor.author | Zhou, Y | - |
dc.contributor.author | Wu, C | - |
dc.contributor.author | Huang, W | - |
dc.contributor.author | Yuan, F | - |
dc.contributor.author | Chen, J | - |
dc.contributor.author | Wu, Z | - |
dc.contributor.author | Tu, W | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Chen, Q | - |
dc.contributor.author | Zhu, M | - |
dc.contributor.author | Peng, H | - |
dc.contributor.author | Yang, Y | - |
dc.contributor.author | Tang, H | - |
dc.date.accessioned | 2021-05-26T03:28:52Z | - |
dc.date.available | 2021-05-26T03:28:52Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Science Bulletin, 2021, Epub 2021-01-26 | - |
dc.identifier.issn | 2095-9273 | - |
dc.identifier.uri | http://hdl.handle.net/10722/299774 | - |
dc.description.abstract | CD1d-restricted natural killer T (NKT) cells are innate-like T lymphocytes with protective or pathogenic roles in the development of influenza pneumonia. Here, we show that lung-infiltrated and activated NKT cells are the major cellular source of LIGHT/TNFSF14, which determines the severity of pulmonary pneumonia by highly deteriorative influenza A virus (IAV) infection. Compared to wild-type mice, LIGHT−/− mice exhibit much lower morbidity and mortality to IAV, due to alleviated lung damage and reduced apoptosis of alveolar macrophages (AMs). LIGHT preferentially promotes cell death of lymphotoxin β receptors positive (LTβR+) AMs but not herpesvirus entry mediator positive (HVEM+) AMs. Therefore, these results suggest that NKT-derived LIGHT augments cell death of the tissue protective AMs in exacerbating lung pathology and susceptibility to fatal influenza infection. Suppression of LIGHT signaling might be a viable option in the treatment of influenza-associated acute respiratory distress syndrome. | - |
dc.language | eng | - |
dc.publisher | Elsevier B.V. and Science China Press. The Journal's web site is located at http://www.sciencedirect.com/science/journal/20959273?sdc=1 | - |
dc.relation.ispartof | Science Bulletin | - |
dc.subject | Influenza A virus | - |
dc.subject | LIGHT/TNFSF14 | - |
dc.subject | Natural killer T cells | - |
dc.subject | Alveolar macrophages | - |
dc.title | LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia | - |
dc.type | Article | - |
dc.identifier.email | Tu, W: wwtu@hku.hk | - |
dc.identifier.authority | Tu, W=rp00416 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.scib.2021.01.026 | - |
dc.identifier.scopus | eid_2-s2.0-85102854228 | - |
dc.identifier.hkuros | 322497 | - |
dc.identifier.volume | Epub 2021-01-26 | - |
dc.identifier.isi | WOS:000697020100013 | - |
dc.publisher.place | United States | - |