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- Publisher Website: 10.1016/j.bmcl.2009.02.116
- Scopus: eid_2-s2.0-63149164406
- PMID: 19297155
- WOS: WOS:000264706800015
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Article: Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
Title | Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein |
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Authors | |
Keywords | Synthesis Acylhydrazones HIV-1 capsid Antiviral activity |
Issue Date | 2009 |
Citation | Bioorganic and Medicinal Chemistry Letters, 2009, v. 19, n. 8, p. 2162-2167 How to Cite? |
Abstract | HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC values of 0.21 and 0.17 μΜ, respectively. © 2009 Elsevier Ltd. All rights reserved. 50 |
Persistent Identifier | http://hdl.handle.net/10722/300161 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.508 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tian, Baohe | - |
dc.contributor.author | He, Meizi | - |
dc.contributor.author | Tang, Shixing | - |
dc.contributor.author | Hewlett, Indira | - |
dc.contributor.author | Tan, Zhiwu | - |
dc.contributor.author | Li, Jiebo | - |
dc.contributor.author | Jin, Yinxue | - |
dc.contributor.author | Yang, Ming | - |
dc.date.accessioned | 2021-06-04T05:49:10Z | - |
dc.date.available | 2021-06-04T05:49:10Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters, 2009, v. 19, n. 8, p. 2162-2167 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10722/300161 | - |
dc.description.abstract | HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC values of 0.21 and 0.17 μΜ, respectively. © 2009 Elsevier Ltd. All rights reserved. 50 | - |
dc.language | eng | - |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry Letters | - |
dc.subject | Synthesis | - |
dc.subject | Acylhydrazones | - |
dc.subject | HIV-1 capsid | - |
dc.subject | Antiviral activity | - |
dc.title | Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bmcl.2009.02.116 | - |
dc.identifier.pmid | 19297155 | - |
dc.identifier.scopus | eid_2-s2.0-63149164406 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 2162 | - |
dc.identifier.epage | 2167 | - |
dc.identifier.isi | WOS:000264706800015 | - |