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- Publisher Website: 10.1016/j.bmc.2010.02.003
- Scopus: eid_2-s2.0-77649235297
- PMID: 20188575
- WOS: WOS:000275513700009
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Article: SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA
Title | SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA |
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Authors | |
Keywords | Antiviral HIV-1 Acylhydrazone derivatives Capsid assembly |
Issue Date | 2010 |
Citation | Bioorganic and Medicinal Chemistry, 2010, v. 18, n. 6, p. 2135-2140 How to Cite? |
Abstract | We synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. © 2010. |
Persistent Identifier | http://hdl.handle.net/10722/300163 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.614 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jin, Yinxue | - |
dc.contributor.author | Tan, Zhiwu | - |
dc.contributor.author | He, Meizi | - |
dc.contributor.author | Tian, Baohe | - |
dc.contributor.author | Tang, Shixing | - |
dc.contributor.author | Hewlett, Indira | - |
dc.contributor.author | Yang, Ming | - |
dc.date.accessioned | 2021-06-04T05:49:11Z | - |
dc.date.available | 2021-06-04T05:49:11Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry, 2010, v. 18, n. 6, p. 2135-2140 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300163 | - |
dc.description.abstract | We synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. © 2010. | - |
dc.language | eng | - |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry | - |
dc.subject | Antiviral | - |
dc.subject | HIV-1 | - |
dc.subject | Acylhydrazone derivatives | - |
dc.subject | Capsid assembly | - |
dc.title | SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bmc.2010.02.003 | - |
dc.identifier.pmid | 20188575 | - |
dc.identifier.scopus | eid_2-s2.0-77649235297 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 2135 | - |
dc.identifier.epage | 2140 | - |
dc.identifier.isi | WOS:000275513700009 | - |