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Article: Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia

TitleSocial brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia
Authors
KeywordsSocial brain network
Social network
Network analysis
Schizophrenia
Social anhedonia
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2021, v. 232, p. 77-84 How to Cite?
AbstractSocial behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting-state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders.
Persistent Identifierhttp://hdl.handle.net/10722/300334
ISSN
2020 Impact Factor: 4.939
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorZhang, YJ-
dc.contributor.authorPu, CC-
dc.contributor.authorWang, YM-
dc.contributor.authorZhang, RT-
dc.contributor.authorCai, XL-
dc.contributor.authorZhou, SZ-
dc.contributor.authorMa, YT-
dc.contributor.authorWang, Y-
dc.contributor.authorCheung, EFC-
dc.contributor.authorLui, SSY-
dc.contributor.authorYu, X-
dc.contributor.authorChan, RCK-
dc.date.accessioned2021-06-04T08:41:27Z-
dc.date.available2021-06-04T08:41:27Z-
dc.date.issued2021-
dc.identifier.citationSchizophrenia Research, 2021, v. 232, p. 77-84-
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/300334-
dc.description.abstractSocial behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting-state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Research-
dc.subjectSocial brain network-
dc.subjectSocial network-
dc.subjectNetwork analysis-
dc.subjectSchizophrenia-
dc.subjectSocial anhedonia-
dc.titleSocial brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia-
dc.typeArticle-
dc.identifier.emailLui, SSY: lsy570@hku.hk-
dc.identifier.emailChan, RCK: rckchan@hkucc.hku.hk-
dc.identifier.authorityLui, SSY=rp02747-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2021.05.016-
dc.identifier.pmid34044349-
dc.identifier.scopuseid_2-s2.0-85106357095-
dc.identifier.hkuros322629-
dc.identifier.volume232-
dc.identifier.spage77-
dc.identifier.epage84-
dc.publisher.placeNetherlands-

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