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Article: Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene

TitleGenetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene
Authors
KeywordsSHANK genes
ADHD
ASD
genetic overlap
pleiotropic gene
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience
Citation
Frontiers in Neuroscience, 2021, v. 15, p. article no. 649588 How to Cite?
AbstractBackground: Recent findings indicated a high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), as well as shared genetic influences on them. The latter might contribute at least partly to the former clinical scenario. This study aimed at investigating whether SHANK genes were potential pleiotropic genes to the two said disorders, underlying their genetic overlap. Methods: This study recruited 298 boys with ADHD (including 256 family trios of 1 ADHD boy and his 2 biological parents), 134 boys with ASD, 109 boys with both ADHD and ASD, and 232 typically developing boys as community controls. They were aged between 6 and 11 years old. Results: There was no significant difference in allele frequency of a number of single nucleotide polymorphisms (SNPs) in SHANK2/SHANK3 between the three clinical groups (ADHD, ASD, and ADHD + ASD) and between the two control groups (community controls and pseudo-controls), respectively. The three clinical groups and the two control groups were thus, respectively, combined. A comparison between the two aggregated samples identified significant evidence of disease association for three SHANK2 SNPs with both ADHD and ASD, even after multiple testing correction: rs11236616 (OR = 0.762, permuted p = 0.0376), rs7106631 (OR = 0.720, permuted p = 0.0034), and rs9888288 (OR = 0.770, permuted p = 0.0407). Comparisons among individual groups pointed to a similar trend of findings. Conclusion: SHANK2 could be considered a potential pleiotropic gene underlying the genetic overlap between ADHD and ASD. This might contribute partly to their high comorbidity in the afflicted children.
Persistent Identifierhttp://hdl.handle.net/10722/300335
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.063
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, SL-
dc.contributor.authorChen, LH-
dc.contributor.authorLee, CC-
dc.contributor.authorLai, KYC-
dc.contributor.authorHung, SF-
dc.contributor.authorTang, CP-
dc.contributor.authorHo, TP-
dc.contributor.authorShea, C-
dc.contributor.authorMo, F-
dc.contributor.authorMak, TSH-
dc.contributor.authorSham, PC-
dc.contributor.authorLeung, PWL-
dc.date.accessioned2021-06-04T08:41:28Z-
dc.date.available2021-06-04T08:41:28Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Neuroscience, 2021, v. 15, p. article no. 649588-
dc.identifier.issn1662-453X-
dc.identifier.urihttp://hdl.handle.net/10722/300335-
dc.description.abstractBackground: Recent findings indicated a high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), as well as shared genetic influences on them. The latter might contribute at least partly to the former clinical scenario. This study aimed at investigating whether SHANK genes were potential pleiotropic genes to the two said disorders, underlying their genetic overlap. Methods: This study recruited 298 boys with ADHD (including 256 family trios of 1 ADHD boy and his 2 biological parents), 134 boys with ASD, 109 boys with both ADHD and ASD, and 232 typically developing boys as community controls. They were aged between 6 and 11 years old. Results: There was no significant difference in allele frequency of a number of single nucleotide polymorphisms (SNPs) in SHANK2/SHANK3 between the three clinical groups (ADHD, ASD, and ADHD + ASD) and between the two control groups (community controls and pseudo-controls), respectively. The three clinical groups and the two control groups were thus, respectively, combined. A comparison between the two aggregated samples identified significant evidence of disease association for three SHANK2 SNPs with both ADHD and ASD, even after multiple testing correction: rs11236616 (OR = 0.762, permuted p = 0.0376), rs7106631 (OR = 0.720, permuted p = 0.0034), and rs9888288 (OR = 0.770, permuted p = 0.0407). Comparisons among individual groups pointed to a similar trend of findings. Conclusion: SHANK2 could be considered a potential pleiotropic gene underlying the genetic overlap between ADHD and ASD. This might contribute partly to their high comorbidity in the afflicted children.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience-
dc.relation.ispartofFrontiers in Neuroscience-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectSHANK genes-
dc.subjectADHD-
dc.subjectASD-
dc.subjectgenetic overlap-
dc.subjectpleiotropic gene-
dc.titleGenetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene-
dc.typeArticle-
dc.identifier.emailChen, LH: luhua@hku.hk-
dc.identifier.emailHo, TP: hrmchtp@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.authoritySham, PC=rp00459-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fnins.2021.649588-
dc.identifier.pmid33986640-
dc.identifier.pmcidPMC8111170-
dc.identifier.scopuseid_2-s2.0-85105633970-
dc.identifier.hkuros322660-
dc.identifier.volume15-
dc.identifier.spagearticle no. 649588-
dc.identifier.epagearticle no. 649588-
dc.identifier.isiWOS:000648900800001-
dc.publisher.placeSwitzerland-

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