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Conference Paper: New Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization

TitleNew Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization
Authors
Li, XC
Issue Date2020
Citation
AsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference, Kyoto, Japan, 24 - 26 February, 2020 How to Cite?
AbstractOver the past decade at the University of Hong Kong, our laboratory has developed several innovative methods for synthetic biologics, including Serine/Threonine Ligation (STL) for protein chemical synthesis, P-B desulfurization for chemoselective peptide desulfurization, OPA bioconjugation for protein modification and OPA chemoselective peptide cyclization. These methods have been successfully applied for synthesis of proteins with post-translational modifications, preparation of antibodydrug conjugates, and antibacterial cyclic peptides, including daptomycin and teixobactin.
DescriptionPeptide Track: Constrained and Cyclic Peptides: Synthesis and Manufacturing
Persistent Identifierhttp://hdl.handle.net/10722/300381

 

DC FieldValueLanguage
dc.contributor.authorLi, XC-
dc.date.accessioned2021-06-08T04:43:48Z-
dc.date.available2021-06-08T04:43:48Z-
dc.date.issued2020-
dc.identifier.citationAsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference, Kyoto, Japan, 24 - 26 February, 2020-
dc.identifier.urihttp://hdl.handle.net/10722/300381-
dc.descriptionPeptide Track: Constrained and Cyclic Peptides: Synthesis and Manufacturing-
dc.description.abstractOver the past decade at the University of Hong Kong, our laboratory has developed several innovative methods for synthetic biologics, including Serine/Threonine Ligation (STL) for protein chemical synthesis, P-B desulfurization for chemoselective peptide desulfurization, OPA bioconjugation for protein modification and OPA chemoselective peptide cyclization. These methods have been successfully applied for synthesis of proteins with post-translational modifications, preparation of antibodydrug conjugates, and antibacterial cyclic peptides, including daptomycin and teixobactin.-
dc.languageeng-
dc.relation.ispartofAsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference-
dc.titleNew Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization-
dc.typeConference_Paper-
dc.identifier.emailLi, XC: xuechenl@hku.hk-
dc.identifier.authorityLi, XC=rp00742-
dc.identifier.hkuros311903-

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