File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Bone density and quality in prediabetes among postmenopausal Chinese women: the role of fibroblast growth factor 21

TitleBone density and quality in prediabetes among postmenopausal Chinese women: the role of fibroblast growth factor 21
Authors
Issue Date2020
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
25th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2020. In Hong Kong Medical Journal, 2020, v. 26 n. 1, Suppl. 1, p. 40, abstract no. 68 How to Cite?
AbstractIntroduction: Prediabetes is associated with a worse trabecular bone score (TBS). Fibroblast growth factor 21 (FGF21) has been reported to be implicated in bone metabolism, and its levels are raised in prediabetes and other insulin-resistant states. We compared the bone mineral density (BMD) and TBS between prediabetes and normoglycaemia, and studied the correlation of FGF21 with BMD and TBS. Methods: Chinese postmenopausal women without type 2 diabetes were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study between November 2016 and October 2018, and divided into prediabetes (fasting glucose ≥5.6 mmol/L or haemoglobin A1c ≥5.7%) and normoglycaemia. Both BMD and TBS were measured by dual-energy X-ray absorptiometry. Serum FGF21 levels were measured with an in-house enzyme-linked immunosorbent assay kit. Results: A total of 258 participants were included (130 prediabetes and 128 normoglycaemia). Bone mineral density was comparable between prediabetes and normoglycaemia, while TBS was lower in prediabetes (1.27±0.07 vs 1.30±0.07, P=0.007), which remained significant after adjustment for age and body mass index. Fibroblast growth factor 21 did not correlate with BMD but inversely correlated with TBS. On stepwise multiple linear regression models, FGF21 showed an independent inverse correlation with TBS (standardised beta -0.13, P=0.031), and remained significant with the inclusion in the model of homeostasis model assessment of insulin resistance. Conclusion: Among Chinese postmenopausal women, the bone quality was worse in prediabetes despite comparable bone density. Fibroblast growth factor 21 showed a significant independent correlation with TBS, suggesting its potential impact on the deterioration of the bone microarchitecture in prediabetes.
Persistent Identifierhttp://hdl.handle.net/10722/300820
ISSN
2020 Impact Factor: 2.227
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLui, TWD-
dc.contributor.authorLee, CH-
dc.contributor.authorChau, VWK-
dc.contributor.authorFong, CHY-
dc.contributor.authorYeung, KMY-
dc.contributor.authorLam, JKY-
dc.contributor.authorLee, ACH-
dc.contributor.authorChow, WS-
dc.contributor.authorTan, KCB-
dc.contributor.authorWoo, YC-
dc.contributor.authorLam, KSL-
dc.date.accessioned2021-07-06T03:10:41Z-
dc.date.available2021-07-06T03:10:41Z-
dc.date.issued2020-
dc.identifier.citation25th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2020. In Hong Kong Medical Journal, 2020, v. 26 n. 1, Suppl. 1, p. 40, abstract no. 68-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/300820-
dc.description.abstractIntroduction: Prediabetes is associated with a worse trabecular bone score (TBS). Fibroblast growth factor 21 (FGF21) has been reported to be implicated in bone metabolism, and its levels are raised in prediabetes and other insulin-resistant states. We compared the bone mineral density (BMD) and TBS between prediabetes and normoglycaemia, and studied the correlation of FGF21 with BMD and TBS. Methods: Chinese postmenopausal women without type 2 diabetes were recruited from the Hong Kong Cardiovascular Risk Factor Prevalence Study between November 2016 and October 2018, and divided into prediabetes (fasting glucose ≥5.6 mmol/L or haemoglobin A1c ≥5.7%) and normoglycaemia. Both BMD and TBS were measured by dual-energy X-ray absorptiometry. Serum FGF21 levels were measured with an in-house enzyme-linked immunosorbent assay kit. Results: A total of 258 participants were included (130 prediabetes and 128 normoglycaemia). Bone mineral density was comparable between prediabetes and normoglycaemia, while TBS was lower in prediabetes (1.27±0.07 vs 1.30±0.07, P=0.007), which remained significant after adjustment for age and body mass index. Fibroblast growth factor 21 did not correlate with BMD but inversely correlated with TBS. On stepwise multiple linear regression models, FGF21 showed an independent inverse correlation with TBS (standardised beta -0.13, P=0.031), and remained significant with the inclusion in the model of homeostasis model assessment of insulin resistance. Conclusion: Among Chinese postmenopausal women, the bone quality was worse in prediabetes despite comparable bone density. Fibroblast growth factor 21 showed a significant independent correlation with TBS, suggesting its potential impact on the deterioration of the bone microarchitecture in prediabetes.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.relation.ispartof25th Medical Research Conference, 2020-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleBone density and quality in prediabetes among postmenopausal Chinese women: the role of fibroblast growth factor 21-
dc.typeConference_Paper-
dc.identifier.emailLui, TWD: dtwlui@hku.hk-
dc.identifier.emailChau, VWK: chauwk3@hku.hk-
dc.identifier.emailLam, JKY: lamkyj@hku.hk-
dc.identifier.emailLee, ACH: achlee@hku.hk-
dc.identifier.emailTan, KCB: kcbtan@hku.hk-
dc.identifier.emailWoo, YC: wooyucho@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityLui, TWD=rp02803-
dc.identifier.authorityTan, KCB=rp00402-
dc.identifier.authorityLam, KSL=rp00343-
dc.description.natureabstract-
dc.identifier.hkuros323150-
dc.identifier.volume26-
dc.identifier.issue1, Suppl. 1-
dc.identifier.spage40, abstract no. 68-
dc.identifier.epage40, abstract no. 68-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats