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- Publisher Website: 10.3389/fimmu.2020.594609
- Scopus: eid_2-s2.0-85098235505
- PMID: 33381115
- WOS: WOS:000602584100001
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Article: Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors
Title | Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors |
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Authors | |
Keywords | T-cell exclusion cell therapy immunotherapy cytokine chemokine |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology |
Citation | Frontiers in Immunology, 2020, v. 11, p. article no. 594609 How to Cite? |
Abstract | The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficking to the tumor core, surviving and expanding, and maintaining the memory phenotype for long-lasting responses. Cytokines and chemokines play critical roles in modulating the recruitment of T cells and the overall cellular compositions of the tumor microenvironment. Manipulating the cytokine or chemokine environment has brought success in preclinical models and early-stage clinical trials. However, depending on the immune context, the same cytokine or chemokine signals may exhibit either antitumor or protumor activities and induce unwanted side effects. Therefore, a comprehensive understanding of the cytokine and chemokine signals is the premise of overcoming T-cell exclusion for effective and innovative anti-cancer therapies. |
Persistent Identifier | http://hdl.handle.net/10722/300925 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.868 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ZHANG, Y | - |
dc.contributor.author | Guan, XY | - |
dc.contributor.author | Jiang, P | - |
dc.date.accessioned | 2021-07-06T03:12:08Z | - |
dc.date.available | 2021-07-06T03:12:08Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Immunology, 2020, v. 11, p. article no. 594609 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300925 | - |
dc.description.abstract | The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficking to the tumor core, surviving and expanding, and maintaining the memory phenotype for long-lasting responses. Cytokines and chemokines play critical roles in modulating the recruitment of T cells and the overall cellular compositions of the tumor microenvironment. Manipulating the cytokine or chemokine environment has brought success in preclinical models and early-stage clinical trials. However, depending on the immune context, the same cytokine or chemokine signals may exhibit either antitumor or protumor activities and induce unwanted side effects. Therefore, a comprehensive understanding of the cytokine and chemokine signals is the premise of overcoming T-cell exclusion for effective and innovative anti-cancer therapies. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology | - |
dc.relation.ispartof | Frontiers in Immunology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | T-cell exclusion | - |
dc.subject | cell therapy | - |
dc.subject | immunotherapy | - |
dc.subject | cytokine | - |
dc.subject | chemokine | - |
dc.title | Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors | - |
dc.type | Article | - |
dc.identifier.email | Guan, XY: xyguan@hku.hk | - |
dc.identifier.authority | Guan, XY=rp00454 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fimmu.2020.594609 | - |
dc.identifier.pmid | 33381115 | - |
dc.identifier.pmcid | PMC7768018 | - |
dc.identifier.scopus | eid_2-s2.0-85098235505 | - |
dc.identifier.hkuros | 323267 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 594609 | - |
dc.identifier.epage | article no. 594609 | - |
dc.identifier.isi | WOS:000602584100001 | - |
dc.publisher.place | Switzerland | - |