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Article: Post-traumatic stress symptoms and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients
Title | Post-traumatic stress symptoms and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients |
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Authors | |
Keywords | 5-HTTLPR polymorphism breast cancer post-traumatic stress symptoms post-traumatic stress disorder serotonine transporter |
Issue Date | 2021 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry |
Citation | Frontiers in Psychiatry, 2021, v. 12, p. article no. 632596 How to Cite? |
Abstract | Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE).
Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis.
Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750).
Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress. |
Persistent Identifier | http://hdl.handle.net/10722/300988 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.155 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zerbinati, L | - |
dc.contributor.author | Murri, MB | - |
dc.contributor.author | Caruso, R | - |
dc.contributor.author | Nanni, MG | - |
dc.contributor.author | Lam, W | - |
dc.contributor.author | De Padova, S | - |
dc.contributor.author | Sabato, S | - |
dc.contributor.author | Bertlli, T | - |
dc.contributor.author | Schillani, G | - |
dc.contributor.author | Giraldi, TL | - |
dc.contributor.author | Fielding, R | - |
dc.contributor.author | Grassi, LUIGI | - |
dc.date.accessioned | 2021-07-06T03:12:59Z | - |
dc.date.available | 2021-07-06T03:12:59Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Frontiers in Psychiatry, 2021, v. 12, p. article no. 632596 | - |
dc.identifier.issn | 1664-0640 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300988 | - |
dc.description.abstract | Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE). Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis. Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750). Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry | - |
dc.relation.ispartof | Frontiers in Psychiatry | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | 5-HTTLPR polymorphism | - |
dc.subject | breast cancer | - |
dc.subject | post-traumatic stress symptoms | - |
dc.subject | post-traumatic stress disorder | - |
dc.subject | serotonine transporter | - |
dc.title | Post-traumatic stress symptoms and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients | - |
dc.type | Article | - |
dc.identifier.email | Lam, W: wwtlam@hku.hk | - |
dc.identifier.email | Fielding, R: fielding@hku.hk | - |
dc.identifier.authority | Lam, W=rp00443 | - |
dc.identifier.authority | Fielding, R=rp00339 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fpsyt.2021.632596 | - |
dc.identifier.pmid | 33967853 | - |
dc.identifier.pmcid | PMC8097040 | - |
dc.identifier.scopus | eid_2-s2.0-85105400944 | - |
dc.identifier.hkuros | 323240 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | article no. 632596 | - |
dc.identifier.epage | article no. 632596 | - |
dc.identifier.isi | WOS:000647000800001 | - |
dc.publisher.place | Switzerland | - |