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Article: An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

TitleAn enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property
Authors
KeywordsBiomimetic mineralization
Enamel-inspired material
Bioactive material
Graphene oxide
Enamel-like structure
Issue Date2022
PublisherElsevier B.V. on behalf of KeAi Communications Co. Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X
Citation
Bioactive Materials, 2022, v. 7, p. 491-503 How to Cite?
AbstractConventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting, acidogenic bacteria invasion of the defective cite. In order to resolve the limitations of the conventional dental materials, the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film. Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure. Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility. In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism, this study brings new prospects for the synthesis of enamel-inspired materials.
Persistent Identifierhttp://hdl.handle.net/10722/301133
ISSN
2023 Impact Factor: 18.0
2023 SCImago Journal Rankings: 3.466
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, HM-
dc.contributor.authorZhang, YY-
dc.contributor.authorLi, QL-
dc.date.accessioned2021-07-27T08:06:36Z-
dc.date.available2021-07-27T08:06:36Z-
dc.date.issued2022-
dc.identifier.citationBioactive Materials, 2022, v. 7, p. 491-503-
dc.identifier.issn2452-199X-
dc.identifier.urihttp://hdl.handle.net/10722/301133-
dc.description.abstractConventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting, acidogenic bacteria invasion of the defective cite. In order to resolve the limitations of the conventional dental materials, the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film. Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure. Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility. In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism, this study brings new prospects for the synthesis of enamel-inspired materials.-
dc.languageeng-
dc.publisherElsevier B.V. on behalf of KeAi Communications Co. Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X-
dc.relation.ispartofBioactive Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBiomimetic mineralization-
dc.subjectEnamel-inspired material-
dc.subjectBioactive material-
dc.subjectGraphene oxide-
dc.subjectEnamel-like structure-
dc.titleAn enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property-
dc.typeArticle-
dc.identifier.emailWong, HM: wonghmg@hkucc.hku.hk-
dc.identifier.authorityWong, HM=rp00042-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bioactmat.2021.05.035-
dc.identifier.pmid34466748-
dc.identifier.pmcidPMC8379364-
dc.identifier.scopuseid_2-s2.0-85108510403-
dc.identifier.hkuros323585-
dc.identifier.volume7-
dc.identifier.spage491-
dc.identifier.epage503-
dc.identifier.isiWOS:000709370300039-
dc.publisher.placeChina-

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