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Article: Detection of methylated septin 9 DNA in blood for diagnosis, prognosis, and surveillance of colorectal cancer

TitleDetection of methylated septin 9 DNA in blood for diagnosis, prognosis, and surveillance of colorectal cancer
Authors
Issue Date2019
PublisherHong Kong Academy of Medicine Press: Open Access Journals. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2019, v. 25 n. 6, suppl. 9, p. 32-34 How to Cite?
Abstract1. The sensitivity of methylated septin9 (mSEPT9) in blood was significantly higher than carcinoembryonic antigen (CEA) in detecting colorectal cancer (CRC) [73.9% vs 48.2%, P<0.001]. However, both were not sensitive enough for detecting colorectal adenoma (<28%). 2. In patients with colorectal cancer, increased number of positive mSEPT9 PCR reactions in plasma samples after surgery was associated with higher rates of mortality (26.3% vs 4.2%, P<0.01), recurrence (47.4% vs 14.1%, P<0.01), and metastasis (36.8% vs 8.5%, P<0.01). 3. In patients with colorectal cancer, the proportion of those with negative CEA was higher than that of those with negative mSEPT9 at 6 months (71.8% vs 55.3%, P=0.035) and 12 months (68.1% vs 48.1%, P=0.028) after surgery.
Persistent Identifierhttp://hdl.handle.net/10722/301134
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorShin, VY-
dc.contributor.authorLaw, WL-
dc.date.accessioned2021-07-27T08:06:37Z-
dc.date.available2021-07-27T08:06:37Z-
dc.date.issued2019-
dc.identifier.citationHong Kong Medical Journal, 2019, v. 25 n. 6, suppl. 9, p. 32-34-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/301134-
dc.description.abstract1. The sensitivity of methylated septin9 (mSEPT9) in blood was significantly higher than carcinoembryonic antigen (CEA) in detecting colorectal cancer (CRC) [73.9% vs 48.2%, P<0.001]. However, both were not sensitive enough for detecting colorectal adenoma (<28%). 2. In patients with colorectal cancer, increased number of positive mSEPT9 PCR reactions in plasma samples after surgery was associated with higher rates of mortality (26.3% vs 4.2%, P<0.01), recurrence (47.4% vs 14.1%, P<0.01), and metastasis (36.8% vs 8.5%, P<0.01). 3. In patients with colorectal cancer, the proportion of those with negative CEA was higher than that of those with negative mSEPT9 at 6 months (71.8% vs 55.3%, P=0.035) and 12 months (68.1% vs 48.1%, P=0.028) after surgery.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press: Open Access Journals. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleDetection of methylated septin 9 DNA in blood for diagnosis, prognosis, and surveillance of colorectal cancer-
dc.typeArticle-
dc.identifier.emailShin, VY: vyshin@hku.hk-
dc.identifier.authorityShin, VY=rp02000-
dc.description.naturepublished_or_final_version-
dc.identifier.pmid31889033-
dc.identifier.scopuseid_2-s2.0-85077314379-
dc.identifier.hkuros323787-
dc.identifier.volume25-
dc.identifier.issue6, suppl. 9-
dc.identifier.spage32-
dc.identifier.epage34-
dc.publisher.placeHong Kong-

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