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Book Chapter: Cell-derived matrices (CDM) - Methods, challenges and applications

TitleCell-derived matrices (CDM) - Methods, challenges and applications
Authors
KeywordsCell-derived matrix
Extracellular matrix
Decellularization
Microencapsulation
Mesenchymal stem cells
Issue Date2020
PublisherAcademic Press
Citation
Cell-derived matrices (CDM) - Methods, challenges and applications. In Caballero, D; Kundu, S & Reis, R (Eds.), Methods in Cell Biology, v. 156: Cell-derived Matrices - Part A, p. 235-258. Cambridge, MA: Academic Press, 2020 How to Cite?
AbstractExtracellular matrix (ECM) provides both physical support and bioactive signals such as growth factors and cytokines to cells at their microenvironment or niche. Engineering the matrix niche becomes an important approach to study or manipulate cellular fate. This work presents an overview on the reconstitution of the ECM niche through a wide range of approaches ranging from coating culture dish with ECM molecules to decellularization of native tissues. In particular, we focused on reconstituting the complex ECM niche through cell-derived matrix (CDM) by reviewing the methodological approaches used in our group to derive ECM from mature cells such as chondrocytes and nucleus pulposus cells (NPCs), undifferentiated stem cells such as mesenchymal stem cells (MSCs), as well as MSCs undergoing chondrogenic and osteogenic differentiation, in 2D or 3D models. Specific attention has also been given to key factors that should be considered in various applications and challenges in relation to the CDM. Last but not the least, a few future perspectives and their significance have been proposed.
DescriptionChapter 10
Persistent Identifierhttp://hdl.handle.net/10722/301221
ISBN
ISSN
2020 Impact Factor: 1.441
2020 SCImago Journal Rankings: 1.329
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, HW-
dc.contributor.authorYuan, M-
dc.contributor.authorLi, CW-
dc.contributor.authorChan, BP-
dc.date.accessioned2021-07-27T08:07:55Z-
dc.date.available2021-07-27T08:07:55Z-
dc.date.issued2020-
dc.identifier.citationCell-derived matrices (CDM) - Methods, challenges and applications. In Caballero, D; Kundu, S & Reis, R (Eds.), Methods in Cell Biology, v. 156: Cell-derived Matrices - Part A, p. 235-258. Cambridge, MA: Academic Press, 2020-
dc.identifier.isbn9780128201725-
dc.identifier.issn0091-679X-
dc.identifier.urihttp://hdl.handle.net/10722/301221-
dc.descriptionChapter 10-
dc.description.abstractExtracellular matrix (ECM) provides both physical support and bioactive signals such as growth factors and cytokines to cells at their microenvironment or niche. Engineering the matrix niche becomes an important approach to study or manipulate cellular fate. This work presents an overview on the reconstitution of the ECM niche through a wide range of approaches ranging from coating culture dish with ECM molecules to decellularization of native tissues. In particular, we focused on reconstituting the complex ECM niche through cell-derived matrix (CDM) by reviewing the methodological approaches used in our group to derive ECM from mature cells such as chondrocytes and nucleus pulposus cells (NPCs), undifferentiated stem cells such as mesenchymal stem cells (MSCs), as well as MSCs undergoing chondrogenic and osteogenic differentiation, in 2D or 3D models. Specific attention has also been given to key factors that should be considered in various applications and challenges in relation to the CDM. Last but not the least, a few future perspectives and their significance have been proposed.-
dc.languageeng-
dc.publisherAcademic Press-
dc.relation.ispartofMethods in Cell Biology, v. 156: Cell-derived Matrices - Part A-
dc.subjectCell-derived matrix-
dc.subjectExtracellular matrix-
dc.subjectDecellularization-
dc.subjectMicroencapsulation-
dc.subjectMesenchymal stem cells-
dc.titleCell-derived matrices (CDM) - Methods, challenges and applications-
dc.typeBook_Chapter-
dc.identifier.emailCheng, HW: vernty@hku.hk-
dc.identifier.emailYuan, M: mintyuan@hku.hk-
dc.identifier.emailChan, BP: bpchan@hku.hk-
dc.identifier.authorityChan, BP=rp00087-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/bs.mcb.2020.01.001-
dc.identifier.hkuros323808-
dc.identifier.spage235-
dc.identifier.epage258-
dc.identifier.isiWOS:000611823400011-
dc.publisher.placeCambridge, MA-

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