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Article: Construction of diverse peptide structural architectures via chemoselective peptide ligation

TitleConstruction of diverse peptide structural architectures via chemoselective peptide ligation
Authors
Issue Date2021
PublisherRoyal Society of Chemistry: Open Access Journals. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2021, v. 12 n. 20, p. 7091-7097 How to Cite?
AbstractHerein, we report the development of a facile synthetic strategy for constructing diverse peptide structural architectures via chemoselective peptide ligation. The key advancement involved is to utilize the benzofuran moiety as the peptide salicylaldehyde ester surrogate, and Dap–Ser/Lys–Ser dipeptide as the hydroxyl amino functionality, which could be successfully introduced at the side chain of peptides enabling peptide ligation. With this method, the side chain-to-side chain cyclic peptide, branched/bridged peptides, tailed cyclic peptides and multi-cyclic peptides have been designed and successfully synthesized with native peptidic linkages at the ligation sites. This strategy has provided an alternative strategic opportunity for synthetic peptide development. It also serves as an inspiration for the structural design of PPI inhibitors with new modalities.
Persistent Identifierhttp://hdl.handle.net/10722/301226
ISSN
2023 Impact Factor: 7.6
2023 SCImago Journal Rankings: 2.333
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, CHP-
dc.contributor.authorXu, J-
dc.contributor.authorLee, CL-
dc.contributor.authorZhang, Y-
dc.contributor.authorWei, R-
dc.contributor.authorBierer, D-
dc.contributor.authorHuang, X-
dc.contributor.authorLi, XC-
dc.date.accessioned2021-07-27T08:07:59Z-
dc.date.available2021-07-27T08:07:59Z-
dc.date.issued2021-
dc.identifier.citationChemical Science, 2021, v. 12 n. 20, p. 7091-7097-
dc.identifier.issn2041-6520-
dc.identifier.urihttp://hdl.handle.net/10722/301226-
dc.description.abstractHerein, we report the development of a facile synthetic strategy for constructing diverse peptide structural architectures via chemoselective peptide ligation. The key advancement involved is to utilize the benzofuran moiety as the peptide salicylaldehyde ester surrogate, and Dap–Ser/Lys–Ser dipeptide as the hydroxyl amino functionality, which could be successfully introduced at the side chain of peptides enabling peptide ligation. With this method, the side chain-to-side chain cyclic peptide, branched/bridged peptides, tailed cyclic peptides and multi-cyclic peptides have been designed and successfully synthesized with native peptidic linkages at the ligation sites. This strategy has provided an alternative strategic opportunity for synthetic peptide development. It also serves as an inspiration for the structural design of PPI inhibitors with new modalities.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry: Open Access Journals. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp-
dc.relation.ispartofChemical Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleConstruction of diverse peptide structural architectures via chemoselective peptide ligation-
dc.typeArticle-
dc.identifier.emailLi, XC: xuechenl@hku.hk-
dc.identifier.authorityLi, XC=rp00742-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1039/D1SC01174J-
dc.identifier.pmid34123337-
dc.identifier.pmcidPMC8153220-
dc.identifier.scopuseid_2-s2.0-85106923367-
dc.identifier.hkuros323619-
dc.identifier.volume12-
dc.identifier.issue20-
dc.identifier.spage7091-
dc.identifier.epage7097-
dc.identifier.isiWOS:000642430000001-
dc.publisher.placeUnited Kingdom-

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