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Article: Relation between rich-club organization versus brain functions and functional recovery after acute ischemic stroke

TitleRelation between rich-club organization versus brain functions and functional recovery after acute ischemic stroke
Authors
KeywordsStroke recovery
Diffusion-weighted imaging
Structural network
Rich-club organization
Functional prediction
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2021, v. 1763, p. article no. 147441 How to Cite?
AbstractStudies have shown the brain’s rich-club organization may underpin brain function and be associated with various brain disorders. In this study, we aimed to investigate the relation between poststroke brain functions and functional recovery versus the rich-club organization of the structural brain network of patients after first-time acute ischemic stroke. A cohort of 16 acute ischemic stroke patients (11 males) was recruited. Structural brain networks were measured using diffusion tensor imaging within 1 week and at 1, 3 and 6 months after stroke. Motor impairment was assessed using the Upper-Extremity Fugl-Meyer motor scale and activities of daily living using the Barthel Index at the same time points as MRI. The rich-club regions that were stable over the course of stroke recovery included the bilateral dorsolateral superior frontal gyri, right supplementary motor area, and left median cingulate and paracingulate gyri. The network properties that correlated with poststroke brain functions were mainly the ratio between communication cost ratio and density ratio of rich-club, feeder and local connections. The recovery of both motor functions and activities of daily living were correlated with higher normalized rich club coefficients and a shorter length of local connections within a week after stroke. The communication cost ratio of feeder connections, the length of rich-club and local connections, and normalized rich club coefficients were found to be potential prognostic indicators of stroke recovery. Our results provide additional support to the notion that different types of network connections play different roles in brain functions as well as functional recovery.
Persistent Identifierhttp://hdl.handle.net/10722/301267
ISSN
2020 Impact Factor: 3.252
2015 SCImago Journal Rankings: 1.351

 

DC FieldValueLanguage
dc.contributor.authorWang, LU-
dc.contributor.authorXu, X-
dc.contributor.authorLau, KK-
dc.contributor.authorLi, LSW-
dc.contributor.authorWong, YK-
dc.contributor.authorYau, C-
dc.contributor.authorMak, HKF-
dc.contributor.authorHui, ES-
dc.date.accessioned2021-07-27T08:08:36Z-
dc.date.available2021-07-27T08:08:36Z-
dc.date.issued2021-
dc.identifier.citationBrain Research, 2021, v. 1763, p. article no. 147441-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/10722/301267-
dc.description.abstractStudies have shown the brain’s rich-club organization may underpin brain function and be associated with various brain disorders. In this study, we aimed to investigate the relation between poststroke brain functions and functional recovery versus the rich-club organization of the structural brain network of patients after first-time acute ischemic stroke. A cohort of 16 acute ischemic stroke patients (11 males) was recruited. Structural brain networks were measured using diffusion tensor imaging within 1 week and at 1, 3 and 6 months after stroke. Motor impairment was assessed using the Upper-Extremity Fugl-Meyer motor scale and activities of daily living using the Barthel Index at the same time points as MRI. The rich-club regions that were stable over the course of stroke recovery included the bilateral dorsolateral superior frontal gyri, right supplementary motor area, and left median cingulate and paracingulate gyri. The network properties that correlated with poststroke brain functions were mainly the ratio between communication cost ratio and density ratio of rich-club, feeder and local connections. The recovery of both motor functions and activities of daily living were correlated with higher normalized rich club coefficients and a shorter length of local connections within a week after stroke. The communication cost ratio of feeder connections, the length of rich-club and local connections, and normalized rich club coefficients were found to be potential prognostic indicators of stroke recovery. Our results provide additional support to the notion that different types of network connections play different roles in brain functions as well as functional recovery.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres-
dc.relation.ispartofBrain Research-
dc.subjectStroke recovery-
dc.subjectDiffusion-weighted imaging-
dc.subjectStructural network-
dc.subjectRich-club organization-
dc.subjectFunctional prediction-
dc.titleRelation between rich-club organization versus brain functions and functional recovery after acute ischemic stroke-
dc.typeArticle-
dc.identifier.emailLau, KK: gkklau@hku.hk-
dc.identifier.emailMak, HKF: makkf@hku.hk-
dc.identifier.authorityLau, KK=rp01499-
dc.identifier.authorityMak, HKF=rp00533-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2021.147441-
dc.identifier.pmid33753065-
dc.identifier.scopuseid_2-s2.0-85103792419-
dc.identifier.hkuros323780-
dc.identifier.volume1763-
dc.identifier.spagearticle no. 147441-
dc.identifier.epagearticle no. 147441-
dc.publisher.placeNetherlands-

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