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Article: Unilateral adrenalectomy for aldosterone-producing adenoma in Hong Kong: outcomes and factors predicting resolution of hypertension

TitleUnilateral adrenalectomy for aldosterone-producing adenoma in Hong Kong: outcomes and factors predicting resolution of hypertension
Authors
Issue Date2021
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1744-1633
Citation
Surgical Practice, 2021, Epub 2021-07-09 How to Cite?
AbstractObjective: To evaluate surgical outcomes of patients with aldosterone-producing adenoma (APA) over a 6-year period from 2009 to 2014 in Hong Kong, and to derive a new scoring system to predict cure of hypertension after surgery. Methodology: This was a retrospective multi-centre study evaluating 104 APA patients from five major hospitals in Hong Kong. These patients were retrieved using database from Surgical Outcomes Monitoring and Improvement Programme (SOMIP). Their clinical characteristics and surgical outcomes were evaluated. Results: Over a median follow-up period of 5 years, APA patients who had undergone adrenalectomy had an average decrease in systolic and diastolic blood pressure of 16.9 and 4.8 mm Hg respectively. Cure of hypokalaemia, cure of hypertension and improvement in hypertension occurred in 100%, 48.5% and 40% respectively. When a patient had two of the following three parameters, namely, female sex, duration of hypertension ≤5 years and number of anti-hypertensives ≤2, the sensitivity and specificity in achieving cure in hypertension was 79.6% and 70.6%, respectively. Surgical complications were uncommon. Conclusions: Adrenalectomy resulted in resolution of hypokalaemia for all and cure of hypertension in half of the patients with APA. It was safe and effective in curing hyperaldosteronism.
Persistent Identifierhttp://hdl.handle.net/10722/301399
ISSN
2023 Impact Factor: 0.3
2023 SCImago Journal Rankings: 0.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, HT-
dc.contributor.authorLang, BHH-
dc.contributor.authorTan, KCB-
dc.contributor.authorFung, BTC-
dc.contributor.authorLau, EYF-
dc.contributor.authorNg, WK-
dc.contributor.authorChan, KW-
dc.contributor.authorChan, BSY-
dc.contributor.authorLau, IT-
dc.contributor.authorLeung, JYY-
dc.date.accessioned2021-07-27T08:10:28Z-
dc.date.available2021-07-27T08:10:28Z-
dc.date.issued2021-
dc.identifier.citationSurgical Practice, 2021, Epub 2021-07-09-
dc.identifier.issn1744-1625-
dc.identifier.urihttp://hdl.handle.net/10722/301399-
dc.description.abstractObjective: To evaluate surgical outcomes of patients with aldosterone-producing adenoma (APA) over a 6-year period from 2009 to 2014 in Hong Kong, and to derive a new scoring system to predict cure of hypertension after surgery. Methodology: This was a retrospective multi-centre study evaluating 104 APA patients from five major hospitals in Hong Kong. These patients were retrieved using database from Surgical Outcomes Monitoring and Improvement Programme (SOMIP). Their clinical characteristics and surgical outcomes were evaluated. Results: Over a median follow-up period of 5 years, APA patients who had undergone adrenalectomy had an average decrease in systolic and diastolic blood pressure of 16.9 and 4.8 mm Hg respectively. Cure of hypokalaemia, cure of hypertension and improvement in hypertension occurred in 100%, 48.5% and 40% respectively. When a patient had two of the following three parameters, namely, female sex, duration of hypertension ≤5 years and number of anti-hypertensives ≤2, the sensitivity and specificity in achieving cure in hypertension was 79.6% and 70.6%, respectively. Surgical complications were uncommon. Conclusions: Adrenalectomy resulted in resolution of hypokalaemia for all and cure of hypertension in half of the patients with APA. It was safe and effective in curing hyperaldosteronism.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1744-1633-
dc.relation.ispartofSurgical Practice-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleUnilateral adrenalectomy for aldosterone-producing adenoma in Hong Kong: outcomes and factors predicting resolution of hypertension-
dc.typeArticle-
dc.identifier.emailLang, BHH: Blang@hku.hk-
dc.identifier.emailTan, KCB: kcbtan@hkucc.hku.hk-
dc.identifier.authorityLang, BHH=rp01828-
dc.identifier.authorityTan, KCB=rp00402-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1744-1633.12507-
dc.identifier.scopuseid_2-s2.0-85111139169-
dc.identifier.hkuros323653-
dc.identifier.volumeEpub 2021-07-09-
dc.identifier.isiWOS:000679059800001-
dc.publisher.placeAustralia-

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