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Article: Influenza vaccine effectiveness against influenza-associated hospitalization in children in Hong Kong, 2010–2020

TitleInfluenza vaccine effectiveness against influenza-associated hospitalization in children in Hong Kong, 2010–2020
Authors
KeywordsInfluenza
Vaccine effectiveness
Public Health
Issue Date2021
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2021, v. 39 n. 34, p. 4842-4848 How to Cite?
AbstractBackground: Influenza virus infections can cause hospitalizations in children, and annual vaccination of children can provide protection against influenza. Methods: We analyzed a test-negative design study with data spanning from 2010/11 through 2019/20 to evaluate influenza vaccine effectiveness (VE) against influenza hospitalization in children by age group, influenza type/subtype and time period within each season. We enrolled children admitted to hospital with acute febrile respiratory illnesses. Nasopharyngeal aspirates were tested by culture and/or RT-PCR to determine influenza status, and vaccination status was obtained by interviewing parents or legal guardians and was verified where possible. VE was estimated by conditional logistic regression model adjusting for sex, age and age-squared, matching on week. Results: Influenza seasons in Hong Kong are prolonged with influenza-associated hospitalizations occurring in almost every month of the year during the study period. Influenza vaccination was effective in preventing influenza-associated hospitalizations in children of all ages. Influenza VE was higher in younger children than in older children, and higher against hospitalization due to influenza A(H1N1)pdm09 than A(H3N2) and B. Conclusions: The childhood influenza vaccination program in Hong Kong has prevented influenza-associated hospitalizations particularly in younger children. Our findings support the use of influenza vaccines in children as an effective approach to influenza control and prevention.
Persistent Identifierhttp://hdl.handle.net/10722/301607
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChua, H-
dc.contributor.authorKwan, MYW-
dc.contributor.authorChan, ELY-
dc.contributor.authorWong, JSC-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.contributor.authorChiu, SS-
dc.date.accessioned2021-08-09T03:41:32Z-
dc.date.available2021-08-09T03:41:32Z-
dc.date.issued2021-
dc.identifier.citationVaccine, 2021, v. 39 n. 34, p. 4842-4848-
dc.identifier.issn0264-410X-
dc.identifier.urihttp://hdl.handle.net/10722/301607-
dc.description.abstractBackground: Influenza virus infections can cause hospitalizations in children, and annual vaccination of children can provide protection against influenza. Methods: We analyzed a test-negative design study with data spanning from 2010/11 through 2019/20 to evaluate influenza vaccine effectiveness (VE) against influenza hospitalization in children by age group, influenza type/subtype and time period within each season. We enrolled children admitted to hospital with acute febrile respiratory illnesses. Nasopharyngeal aspirates were tested by culture and/or RT-PCR to determine influenza status, and vaccination status was obtained by interviewing parents or legal guardians and was verified where possible. VE was estimated by conditional logistic regression model adjusting for sex, age and age-squared, matching on week. Results: Influenza seasons in Hong Kong are prolonged with influenza-associated hospitalizations occurring in almost every month of the year during the study period. Influenza vaccination was effective in preventing influenza-associated hospitalizations in children of all ages. Influenza VE was higher in younger children than in older children, and higher against hospitalization due to influenza A(H1N1)pdm09 than A(H3N2) and B. Conclusions: The childhood influenza vaccination program in Hong Kong has prevented influenza-associated hospitalizations particularly in younger children. Our findings support the use of influenza vaccines in children as an effective approach to influenza control and prevention.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine-
dc.relation.ispartofVaccine-
dc.subjectInfluenza-
dc.subjectVaccine effectiveness-
dc.subjectPublic Health-
dc.titleInfluenza vaccine effectiveness against influenza-associated hospitalization in children in Hong Kong, 2010–2020-
dc.typeArticle-
dc.identifier.emailChua, H: hychua@hku.hk-
dc.identifier.emailChan, ELY: laiyin@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailChiu, SS: ssschiu@hku.hk-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityChiu, SS=rp00421-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2021.07.014-
dc.identifier.pmid34301433-
dc.identifier.scopuseid_2-s2.0-85111074401-
dc.identifier.hkuros323986-
dc.identifier.volume39-
dc.identifier.issue34-
dc.identifier.spage4842-
dc.identifier.epage4848-
dc.identifier.isiWOS:000679483400015-
dc.publisher.placeUnited Kingdom-

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