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Article: Liposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells

TitleLiposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells
Authors
KeywordsIonophore
Valinomycin, liposomes
Potassium ion efflux
Apoptosis
Cancer therapy
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jconrel
Citation
Journal of Controlled Release, 2021, v. 337, p. 317-328 How to Cite?
AbstractMost cancer therapies are suffering from side effects to varying degrees, which might compromise the body functions and long-term health of patients. Balancing treatment efficacy and side effects has become a priority. Inspired by the concept that cellular ion homeostasis can lead to apoptosis, we developed a novel therapeutic strategy by incorporating the K+ transporter valinomycin into liposomes (Lipo-VM). Valinomycin is a naturally occurring polypeptide showing good biodegradation in vivo with reduced long-term side effects. Lipo-VM facilitates the K+ efflux of cells and triggers a caspase-dependent pathway of apoptosis by causing the collapse of mitochondrial membrane potential. With the help of a liposome-based nano-delivery system, Lipo-VM shows enhanced cell uptake and accumulation at the tumor site, which results in significant inhibition of tumor growth in a liver cancer model. The proposed valinomycin-anchored liposome provides an efficient and safe approach for cancer therapy.
Persistent Identifierhttp://hdl.handle.net/10722/301623
ISSN
2023 Impact Factor: 10.5
2023 SCImago Journal Rankings: 2.157
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, QW-
dc.contributor.authorBaig, MMFA-
dc.contributor.authorZhang, TQ-
dc.contributor.authorZhai, TT-
dc.contributor.authorQin, X-
dc.contributor.authorXia, XH-
dc.date.accessioned2021-08-09T03:41:46Z-
dc.date.available2021-08-09T03:41:46Z-
dc.date.issued2021-
dc.identifier.citationJournal of Controlled Release, 2021, v. 337, p. 317-328-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10722/301623-
dc.description.abstractMost cancer therapies are suffering from side effects to varying degrees, which might compromise the body functions and long-term health of patients. Balancing treatment efficacy and side effects has become a priority. Inspired by the concept that cellular ion homeostasis can lead to apoptosis, we developed a novel therapeutic strategy by incorporating the K+ transporter valinomycin into liposomes (Lipo-VM). Valinomycin is a naturally occurring polypeptide showing good biodegradation in vivo with reduced long-term side effects. Lipo-VM facilitates the K+ efflux of cells and triggers a caspase-dependent pathway of apoptosis by causing the collapse of mitochondrial membrane potential. With the help of a liposome-based nano-delivery system, Lipo-VM shows enhanced cell uptake and accumulation at the tumor site, which results in significant inhibition of tumor growth in a liver cancer model. The proposed valinomycin-anchored liposome provides an efficient and safe approach for cancer therapy.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jconrel-
dc.relation.ispartofJournal of Controlled Release-
dc.subjectIonophore-
dc.subjectValinomycin, liposomes-
dc.subjectPotassium ion efflux-
dc.subjectApoptosis-
dc.subjectCancer therapy-
dc.titleLiposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells-
dc.typeArticle-
dc.identifier.emailBaig, MMFA: faran@hku.hk-
dc.identifier.authorityBaig, MMFA=rp02755-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jconrel.2021.07.037-
dc.identifier.pmid34311027-
dc.identifier.scopuseid_2-s2.0-85111305762-
dc.identifier.hkuros324014-
dc.identifier.volume337-
dc.identifier.spage317-
dc.identifier.epage328-
dc.identifier.isiWOS:000696936500007-
dc.publisher.placeNetherlands-

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