File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Aerobic exercise decreases negative affect by modulating orbitofrontal-amygdala connectivity in adolescents

TitleAerobic exercise decreases negative affect by modulating orbitofrontal-amygdala connectivity in adolescents
Authors
Keywordsacute exercise
negative affect
amygdala
orbitofrontal cortex
depression
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at https://www.mdpi.com/journal/life
Citation
Life, 2021, v. 11, p. article no. 577 How to Cite?
AbstractLong-term negative affect in adolescence is associated with impairment in quality of life, interpersonal function, and social adaptation. Although physical exercise could decrease negative emotion, the underlying mechanism remains largely unknown. Acute exercise with controlled intensity might be a good experimental paradigm to unravel the potential neural mechanisms underlying the effects of physical exercise on negative affect. In this study, twenty-three males in late adolescence were randomly assigned to acute exercise group (AG) or control group. The experiment contained pre-test and post-test session interleaved with 30-min moderate-intensity exercise or seated rest. In each session, a resting-state fMRI scanning was conducted followed by completing Positive and Negative Affect Schedule and Profile of Mood State. Bilateral amygdala was used as seed region to calculate t voxel-wised functional connectivity (FC) of amygdala to whole brain. The results demonstrated, for the first time, that AG exhibited increased FC between right amygdala and right orbital frontal cortex. Significantly decreased negative affect was also observed in AG. Moreover, the increased rOFC-amygdala FC was also associated with the decreased depression score. Our findings suggest that exercise-induced decreased negative affect might be modulated by functional interactions of amygdala with both cognitive control and limbic networks, which offers a meaningful insight for clinical treatment and prevention of emotional disorders in late adolescence.
Persistent Identifierhttp://hdl.handle.net/10722/301725
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.713
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGe, LK-
dc.contributor.authorHu, Z-
dc.contributor.authorWang, W-
dc.contributor.authorSiu, PM-
dc.contributor.authorWei, GX-
dc.date.accessioned2021-08-09T03:43:19Z-
dc.date.available2021-08-09T03:43:19Z-
dc.date.issued2021-
dc.identifier.citationLife, 2021, v. 11, p. article no. 577-
dc.identifier.issn2075-1729-
dc.identifier.urihttp://hdl.handle.net/10722/301725-
dc.description.abstractLong-term negative affect in adolescence is associated with impairment in quality of life, interpersonal function, and social adaptation. Although physical exercise could decrease negative emotion, the underlying mechanism remains largely unknown. Acute exercise with controlled intensity might be a good experimental paradigm to unravel the potential neural mechanisms underlying the effects of physical exercise on negative affect. In this study, twenty-three males in late adolescence were randomly assigned to acute exercise group (AG) or control group. The experiment contained pre-test and post-test session interleaved with 30-min moderate-intensity exercise or seated rest. In each session, a resting-state fMRI scanning was conducted followed by completing Positive and Negative Affect Schedule and Profile of Mood State. Bilateral amygdala was used as seed region to calculate t voxel-wised functional connectivity (FC) of amygdala to whole brain. The results demonstrated, for the first time, that AG exhibited increased FC between right amygdala and right orbital frontal cortex. Significantly decreased negative affect was also observed in AG. Moreover, the increased rOFC-amygdala FC was also associated with the decreased depression score. Our findings suggest that exercise-induced decreased negative affect might be modulated by functional interactions of amygdala with both cognitive control and limbic networks, which offers a meaningful insight for clinical treatment and prevention of emotional disorders in late adolescence.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at https://www.mdpi.com/journal/life-
dc.relation.ispartofLife-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectacute exercise-
dc.subjectnegative affect-
dc.subjectamygdala-
dc.subjectorbitofrontal cortex-
dc.subjectdepression-
dc.titleAerobic exercise decreases negative affect by modulating orbitofrontal-amygdala connectivity in adolescents-
dc.typeArticle-
dc.identifier.emailSiu, PM: pmsiu@hku.hk-
dc.identifier.authoritySiu, PM=rp02292-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/life11060577-
dc.identifier.pmid34207133-
dc.identifier.pmcidPMC8234212-
dc.identifier.scopuseid_2-s2.0-85108887131-
dc.identifier.hkuros324147-
dc.identifier.volume11-
dc.identifier.spagearticle no. 577-
dc.identifier.epagearticle no. 577-
dc.identifier.isiWOS:000666490700001-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats