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- Publisher Website: 10.3390/ijms20235839
- Scopus: eid_2-s2.0-85075284187
- PMID: 31757079
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Article: Nucleoplasmic reticulum formation in human endometrial cells is steroid hormone responsive and recruits nascent components
Title | Nucleoplasmic reticulum formation in human endometrial cells is steroid hormone responsive and recruits nascent components |
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Authors | |
Keywords | Nucleoplasmic reticulum Reproductive cycle Nuclear architecture |
Issue Date | 2019 |
Citation | International Journal of Molecular Sciences, 2019, v. 20, n. 23, article no. 5839 How to Cite? |
Abstract | The nuclei of cells may exhibit invaginations of the nuclear envelope under a variety of conditions. These invaginations form a branched network termed the nucleoplasmic reticulum (NR), which may be found in cells in pathological and physiological conditions. While an extensive NR is a hallmark of cellular senescence and shows associations with some cancers, very little is known about the formation of NR in physiological conditions, despite the presence of extensive nuclear invaginations in some cell types such as endometrial cells. Here we show that in these cells the NR is formed in response to reproductive hormones. We demonstrate that oestrogen and progesterone are sufficient to induce NR formation and that this process is reversible without cell division upon removal of the hormonal stimulus. Nascent lamins and phospholipids are incorporated into the invaginations suggesting that there is a dedicated machinery for its formation. The induction of NR in endometrial cells offers a new model to study NR formation and function in physiological conditions. |
Persistent Identifier | http://hdl.handle.net/10722/301848 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pytowski, Lior | - |
dc.contributor.author | Drozdz, Marek M. | - |
dc.contributor.author | Jiang, Haibo | - |
dc.contributor.author | Hernandez, Zayra | - |
dc.contributor.author | Kumar, Kurun | - |
dc.contributor.author | Knott, Emily | - |
dc.contributor.author | Vaux, David J. | - |
dc.date.accessioned | 2021-08-19T02:20:52Z | - |
dc.date.available | 2021-08-19T02:20:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2019, v. 20, n. 23, article no. 5839 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301848 | - |
dc.description.abstract | The nuclei of cells may exhibit invaginations of the nuclear envelope under a variety of conditions. These invaginations form a branched network termed the nucleoplasmic reticulum (NR), which may be found in cells in pathological and physiological conditions. While an extensive NR is a hallmark of cellular senescence and shows associations with some cancers, very little is known about the formation of NR in physiological conditions, despite the presence of extensive nuclear invaginations in some cell types such as endometrial cells. Here we show that in these cells the NR is formed in response to reproductive hormones. We demonstrate that oestrogen and progesterone are sufficient to induce NR formation and that this process is reversible without cell division upon removal of the hormonal stimulus. Nascent lamins and phospholipids are incorporated into the invaginations suggesting that there is a dedicated machinery for its formation. The induction of NR in endometrial cells offers a new model to study NR formation and function in physiological conditions. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Nucleoplasmic reticulum | - |
dc.subject | Reproductive cycle | - |
dc.subject | Nuclear architecture | - |
dc.title | Nucleoplasmic reticulum formation in human endometrial cells is steroid hormone responsive and recruits nascent components | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms20235839 | - |
dc.identifier.pmid | 31757079 | - |
dc.identifier.pmcid | PMC6929123 | - |
dc.identifier.scopus | eid_2-s2.0-85075284187 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 23 | - |
dc.identifier.spage | article no. 5839 | - |
dc.identifier.epage | article no. 5839 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.isi | WOS:000504428300021 | - |