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Article: Exosomal non-coding RNAs: Regulatory and therapeutic target of hepatocellular carcinoma

TitleExosomal non-coding RNAs: Regulatory and therapeutic target of hepatocellular carcinoma
Authors
Xia, HHuang, ZLiu, SZhao, XHe, RWang, ZShi, WChen, WLi, ZYu, LHuang, PKang, PSu, ZXu, YYam, JWPCui, Y
Keywordsexosomes
non-coding RNAs
hepatocellular carcinoma
tumor microenvironment
early diagnosis
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/oncology
Citation
Frontiers in Oncology, 2021, v. 11, p. article no. 653846 How to Cite?
DOI: http://dx.doi.org/10.3389/fonc.2021.653846
AbstractExosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.
Persistent Identifierhttp://hdl.handle.net/10722/302129
ISSN
2234-943X
2021 Impact Factor: 5.738
2020 SCImago Journal Rankings: 1.834
PubMed Central ID
PMC8044750
ISI Accession Number ID
WOS:000638183900001

 

DC FieldValueLanguage
dc.contributor.authorXia, H-
dc.contributor.authorHuang, Z-
dc.contributor.authorLiu, S-
dc.contributor.authorZhao, X-
dc.contributor.authorHe, R-
dc.contributor.authorWang, Z-
dc.contributor.authorShi, W-
dc.contributor.authorChen, W-
dc.contributor.authorLi, Z-
dc.contributor.authorYu, L-
dc.contributor.authorHuang, P-
dc.contributor.authorKang, P-
dc.contributor.authorSu, Z-
dc.contributor.authorXu, Y-
dc.contributor.authorYam, JWP-
dc.contributor.authorCui, Y-
dc.date.accessioned2021-08-21T03:31:59Z-
dc.date.available2021-08-21T03:31:59Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Oncology, 2021, v. 11, p. article no. 653846-
dc.identifier.issn2234-943X-
dc.identifier.urihttp://hdl.handle.net/10722/302129-
dc.description.abstractExosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/oncology-
dc.relation.ispartofFrontiers in Oncology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectexosomes-
dc.subjectnon-coding RNAs-
dc.subjecthepatocellular carcinoma-
dc.subjecttumor microenvironment-
dc.subjectearly diagnosis-
dc.titleExosomal non-coding RNAs: Regulatory and therapeutic target of hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hk-
dc.identifier.authorityYam, JWP=rp00468-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fonc.2021.653846-
dc.identifier.pmid33869059-
dc.identifier.pmcidPMC8044750-
dc.identifier.scopuseid_2-s2.0-85103882766-
dc.identifier.hkuros324192-
dc.identifier.volume11-
dc.identifier.spagearticle no. 653846-
dc.identifier.epagearticle no. 653846-
dc.identifier.isiWOS:000638183900001-
dc.publisher.placeSwitzerland-

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