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Article: Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value

TitleExosomes in hepatocellular carcinoma microenvironment and their potential clinical application value
Authors
KeywordsHepatocellular carcinoma
Exosome
Microenvironment
Issue Date2021
PublisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha
Citation
Biomedicine & Pharmacotherapy, 2021, v. 138, p. article no. 111529 How to Cite?
AbstractHepatocellular carcinoma (HCC) has become a challenging disease in the world today. Due to the limitations on the current diagnosis and treatment as well as its high metastatic ability and high recurrence rate, HCC gradually becomes the second deadliest tumor. Exosomes are one of the types of cell-derived vesicles and can carry intracellular materials such as genetic materials, lipids, and proteins. In recent years, it has been verified that exosomes are linked to numerous physiological and pathological processes, including HCC. However, how exosomes affect HCC progression remains largely unknown. In this review, the exosome-mediated cellular material transfer between cells of different types in the HCC microenvironment and their effects on the behaviors and functions of recipient cells are studied. Furthermore, we also addressed the underlying molecular mechanisms. We believe that new light on the diagnosis of this cancer as well as its treatment strategies will be shed after a collation of literature in this area.
Persistent Identifierhttp://hdl.handle.net/10722/302130
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.493
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHe, R-
dc.contributor.authorWang, Z-
dc.contributor.authorShi, W-
dc.contributor.authorYu, L-
dc.contributor.authorXia, H-
dc.contributor.authorHuang, Z-
dc.contributor.authorLiu, S-
dc.contributor.authorZhao, X-
dc.contributor.authorXu, Y-
dc.contributor.authorYam, JWP-
dc.contributor.authorCui, Y-
dc.date.accessioned2021-08-21T03:32:00Z-
dc.date.available2021-08-21T03:32:00Z-
dc.date.issued2021-
dc.identifier.citationBiomedicine & Pharmacotherapy, 2021, v. 138, p. article no. 111529-
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/10722/302130-
dc.description.abstractHepatocellular carcinoma (HCC) has become a challenging disease in the world today. Due to the limitations on the current diagnosis and treatment as well as its high metastatic ability and high recurrence rate, HCC gradually becomes the second deadliest tumor. Exosomes are one of the types of cell-derived vesicles and can carry intracellular materials such as genetic materials, lipids, and proteins. In recent years, it has been verified that exosomes are linked to numerous physiological and pathological processes, including HCC. However, how exosomes affect HCC progression remains largely unknown. In this review, the exosome-mediated cellular material transfer between cells of different types in the HCC microenvironment and their effects on the behaviors and functions of recipient cells are studied. Furthermore, we also addressed the underlying molecular mechanisms. We believe that new light on the diagnosis of this cancer as well as its treatment strategies will be shed after a collation of literature in this area.-
dc.languageeng-
dc.publisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha-
dc.relation.ispartofBiomedicine & Pharmacotherapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHepatocellular carcinoma-
dc.subjectExosome-
dc.subjectMicroenvironment-
dc.titleExosomes in hepatocellular carcinoma microenvironment and their potential clinical application value-
dc.typeArticle-
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hk-
dc.identifier.authorityYam, JWP=rp00468-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.biopha.2021.111529-
dc.identifier.pmid34311529-
dc.identifier.scopuseid_2-s2.0-85103131967-
dc.identifier.hkuros324194-
dc.identifier.volume138-
dc.identifier.spagearticle no. 111529-
dc.identifier.epagearticle no. 111529-
dc.identifier.isiWOS:000641405300009-
dc.publisher.placeFrance-

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