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- Publisher Website: 10.1038/s41467-019-10401-y
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- PMID: 31227695
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Article: Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor
Title | Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor |
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Authors | |
Issue Date | 2019 |
Citation | Nature Communications, 2019, v. 10, n. 1, article no. 2741 How to Cite? |
Abstract | Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels. |
Persistent Identifier | http://hdl.handle.net/10722/303612 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Nightingale, Adrian M. | - |
dc.contributor.author | Leong, Chi Leng | - |
dc.contributor.author | Burnish, Rachel A. | - |
dc.contributor.author | Hassan, Sammer ul | - |
dc.contributor.author | Zhang, Yu | - |
dc.contributor.author | Clough, Geraldine F. | - |
dc.contributor.author | Boutelle, Martyn G. | - |
dc.contributor.author | Voegeli, David | - |
dc.contributor.author | Niu, Xize | - |
dc.date.accessioned | 2021-09-15T08:25:40Z | - |
dc.date.available | 2021-09-15T08:25:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nature Communications, 2019, v. 10, n. 1, article no. 2741 | - |
dc.identifier.uri | http://hdl.handle.net/10722/303612 | - |
dc.description.abstract | Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-019-10401-y | - |
dc.identifier.pmid | 31227695 | - |
dc.identifier.pmcid | PMC6588579 | - |
dc.identifier.scopus | eid_2-s2.0-85067598209 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 2741 | - |
dc.identifier.epage | article no. 2741 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000472480500008 | - |