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Article: Ultrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry

TitleUltrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry
Authors
Keywordscentimeter-scale metasurfaces
deterministic gradient geometry
image-based sensing schemes
molecular detection
Issue Date2021
PublisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089
Citation
Advanced Materials, 2021, v. 33 n. 29, p. article no. 2100270 How to Cite?
AbstractHighly sensitive detection of trace amounts of substances is crucial for broad applications in healthcare, environmental monitoring, antiterrorism, etc., where cost effectiveness and portability are often demanded. Here, an ultrasensitive sensor is reported that can detect an angstrom-thick layer of adsorbed molecules through image acquisition and processing. The sensor features a centimeter-scale plasmonic metasurface with spatially varying geometry, where the light scattering is dependent on both the adsorbed substances and spatial locations. When illuminated with narrowband light (such as from a light emitting diode), the intensity pattern recorded on the metasurface changes with the surface-adsorbed molecules, enabling label-free, sensitive, and spectrometer-free molecular detection. The centimeter-scale size of the sensing area interfaces well with consumer-level imaging sensors on mobile devices without the need for microscopic optics and offers a high signal-to-noise ratio by leveraging the multimillion pixels for noise reduction. It is experimentally demonstrated that a single layer of Al2O3 molecules deposited on the sensor, with a thickness of approximately one angstrom, can be detected by analyzing the images taken of the sensing chip. Furthermore, by integrating the sensor into a microfluidic setup, quantitative detection of BSA/anti-BSA immune complex formation events is demonstrated, which agrees well with the Langmuir isotherm model.
Persistent Identifierhttp://hdl.handle.net/10722/303969
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMin, S-
dc.contributor.authorLi, S-
dc.contributor.authorZhu, Z-
dc.contributor.authorLiu, Y-
dc.contributor.authorLiang, C-
dc.contributor.authorCai, J-
dc.contributor.authorHan, F-
dc.contributor.authorLi, Y-
dc.contributor.authorCai, W-
dc.contributor.authorCheng, X-
dc.contributor.authorLi, WD-
dc.date.accessioned2021-09-23T08:53:22Z-
dc.date.available2021-09-23T08:53:22Z-
dc.date.issued2021-
dc.identifier.citationAdvanced Materials, 2021, v. 33 n. 29, p. article no. 2100270-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/303969-
dc.description.abstractHighly sensitive detection of trace amounts of substances is crucial for broad applications in healthcare, environmental monitoring, antiterrorism, etc., where cost effectiveness and portability are often demanded. Here, an ultrasensitive sensor is reported that can detect an angstrom-thick layer of adsorbed molecules through image acquisition and processing. The sensor features a centimeter-scale plasmonic metasurface with spatially varying geometry, where the light scattering is dependent on both the adsorbed substances and spatial locations. When illuminated with narrowband light (such as from a light emitting diode), the intensity pattern recorded on the metasurface changes with the surface-adsorbed molecules, enabling label-free, sensitive, and spectrometer-free molecular detection. The centimeter-scale size of the sensing area interfaces well with consumer-level imaging sensors on mobile devices without the need for microscopic optics and offers a high signal-to-noise ratio by leveraging the multimillion pixels for noise reduction. It is experimentally demonstrated that a single layer of Al2O3 molecules deposited on the sensor, with a thickness of approximately one angstrom, can be detected by analyzing the images taken of the sensing chip. Furthermore, by integrating the sensor into a microfluidic setup, quantitative detection of BSA/anti-BSA immune complex formation events is demonstrated, which agrees well with the Langmuir isotherm model.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2089-
dc.relation.ispartofAdvanced Materials-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectcentimeter-scale metasurfaces-
dc.subjectdeterministic gradient geometry-
dc.subjectimage-based sensing schemes-
dc.subjectmolecular detection-
dc.titleUltrasensitive Molecular Detection by Imaging of Centimeter-Scale Metasurfaces with a Deterministic Gradient Geometry-
dc.typeArticle-
dc.identifier.emailLi, WD: liwd@hku.hk-
dc.identifier.authorityLi, WD=rp01581-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.202100270-
dc.identifier.pmid34085723-
dc.identifier.scopuseid_2-s2.0-85107127513-
dc.identifier.hkuros325710-
dc.identifier.volume33-
dc.identifier.issue29-
dc.identifier.spagearticle no. 2100270-
dc.identifier.epagearticle no. 2100270-
dc.identifier.isiWOS:000657695400001-
dc.publisher.placeGermany-

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