File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair

TitleMesenchymal stromal cell-derived exosomes in cardiac regeneration and repair
Authors
Keywordsmesenchymal stromal cell
exosome
myocardial infarction
cardiac regeneration and repair
Issue Date2021
PublisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com
Citation
Stem Cell Reports, 2021, v. 16 n. 7, p. 1662-1673 How to Cite?
AbstractMesenchymal stromal cell (MSC)-derived exosomes play a promising role in regenerative medicine. Their trophic and immunomodulatory potential has made them a promising candidate for cardiac regeneration and repair. Numerous studies have demonstrated that MSC-derived exosomes can replicate the anti-inflammatory, anti-apoptotic, and pro-angiogenic and anti-fibrotic effects of their parent cells and are considered a substitute for cell-based therapies. In addition, their lower tumorigenic risk, superior immune tolerance, and superior stability compared with their parent stem cells make them an attractive option in regenerative medicine. The therapeutic effects of MSC-derived exosomes have consequently been evaluated for application in cardiac regeneration and repair. In this review, we summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
Persistent Identifierhttp://hdl.handle.net/10722/303978
ISSN
2020 Impact Factor: 7.765
2020 SCImago Journal Rankings: 3.207
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSUN, SJ-
dc.contributor.authorWEI, R-
dc.contributor.authorLi, F-
dc.contributor.authorLiao, SY-
dc.contributor.authorTse, HF-
dc.date.accessioned2021-09-23T08:53:30Z-
dc.date.available2021-09-23T08:53:30Z-
dc.date.issued2021-
dc.identifier.citationStem Cell Reports, 2021, v. 16 n. 7, p. 1662-1673-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/10722/303978-
dc.description.abstractMesenchymal stromal cell (MSC)-derived exosomes play a promising role in regenerative medicine. Their trophic and immunomodulatory potential has made them a promising candidate for cardiac regeneration and repair. Numerous studies have demonstrated that MSC-derived exosomes can replicate the anti-inflammatory, anti-apoptotic, and pro-angiogenic and anti-fibrotic effects of their parent cells and are considered a substitute for cell-based therapies. In addition, their lower tumorigenic risk, superior immune tolerance, and superior stability compared with their parent stem cells make them an attractive option in regenerative medicine. The therapeutic effects of MSC-derived exosomes have consequently been evaluated for application in cardiac regeneration and repair. In this review, we summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.-
dc.languageeng-
dc.publisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com-
dc.relation.ispartofStem Cell Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectmesenchymal stromal cell-
dc.subjectexosome-
dc.subjectmyocardial infarction-
dc.subjectcardiac regeneration and repair-
dc.titleMesenchymal stromal cell-derived exosomes in cardiac regeneration and repair-
dc.typeArticle-
dc.identifier.emailLi, F: lf0411@hku.hk-
dc.identifier.emailLiao, SY: lsy923@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityLiao, SY=rp02244-
dc.identifier.authorityTse, HF=rp00428-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.stemcr.2021.05.003-
dc.identifier.pmid34115984-
dc.identifier.pmcidPMC8282428-
dc.identifier.scopuseid_2-s2.0-85109464341-
dc.identifier.hkuros325626-
dc.identifier.volume16-
dc.identifier.issue7-
dc.identifier.spage1662-
dc.identifier.epage1673-
dc.identifier.isiWOS:000674432500006-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats