File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Air dispersal of multidrug-resistant Acinetobacter baumannii: implications for nosocomial transmission during the COVID-19 pandemic

TitleAir dispersal of multidrug-resistant Acinetobacter baumannii: implications for nosocomial transmission during the COVID-19 pandemic
Authors
KeywordsAir
multidrug-resistant
Acinetobacter baumannii
nosocomial
COVID-19
Issue Date2021
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin
Citation
Journal of Hospital Infection, 2021, v. 116, p. 78-86 How to Cite?
AbstractAim: To describe the nosocomial transmission of Air, multidrug-resistant, Acinetobacter baumannii, nosocomial, COVID-19 Acinetobacter baumannii (MRAB) in an open-cubicle neurology ward with low ceiling height, where MRAB isolates collected from air, commonly shared items, non-reachable high-level surfaces and patients were analysed epidemiologically and genetically by whole-genome sequencing. This is the first study to understand the genetic relatedness of air, environmental and clinical isolates of MRAB in the outbreak setting. Findings: Of 11 highly care-dependent patients with 363 MRAB colonization days during COVID-19 pandemic, 10 (90.9%) and nine (81.8%) had cutaneous and gastrointestinal colonization, respectively. Of 160 environmental and air samples, 31 (19.4%) were MRAB-positive. The proportion of MRAB-contaminated commonly shared items was significantly lower in cohort than in non-cohort patient care (0/10, 0% vs 12/18, 66.7%; P<0.001). Air dispersal of MRAB was consistently detected during but not before diaper change in the cohort cubicle by 25-min air sampling (4/4,100% vs 0/4, 0%; P=0.029). The settle plate method revealed MRAB in two samples during diaper change. The proportion of MRAB-contaminated exhaust air grills was significantly higher when the cohort cubicle was occupied by six MRAB patients than when fewer than six patients were cared for in the cubicle (5/9, 55.6% vs 0/18, 0%; P=0.002). The proportion of MRAB-contaminated non-reachable high-level surfaces was also significantly higher when there were three or more MRAB patients in the cohort cubicle (8/31, 25.8% vs 0/24, 0%; P=0.016). Whole-genome sequencing revealed clonality of air, environment, and patients' isolates, suggestive of air dispersal of MRAB. Conclusions: Our findings support the view that patient cohorting in enclosed cubicles with partitions and a closed door is preferred if single rooms are not available.
Persistent Identifierhttp://hdl.handle.net/10722/303988
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.095
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, SC-
dc.contributor.authorLam, GKM-
dc.contributor.authorChen, JHK-
dc.contributor.authorLi, X-
dc.contributor.authorIp, FTF-
dc.contributor.authorYuen, LLH-
dc.contributor.authorChan, VWM-
dc.contributor.authorAuYeung, CHY-
dc.contributor.authorSo, SYC-
dc.contributor.authorHo, PL-
dc.contributor.authorYuen, KY-
dc.contributor.authorCheng, VCC-
dc.date.accessioned2021-09-23T08:53:39Z-
dc.date.available2021-09-23T08:53:39Z-
dc.date.issued2021-
dc.identifier.citationJournal of Hospital Infection, 2021, v. 116, p. 78-86-
dc.identifier.issn0195-6701-
dc.identifier.urihttp://hdl.handle.net/10722/303988-
dc.description.abstractAim: To describe the nosocomial transmission of Air, multidrug-resistant, Acinetobacter baumannii, nosocomial, COVID-19 Acinetobacter baumannii (MRAB) in an open-cubicle neurology ward with low ceiling height, where MRAB isolates collected from air, commonly shared items, non-reachable high-level surfaces and patients were analysed epidemiologically and genetically by whole-genome sequencing. This is the first study to understand the genetic relatedness of air, environmental and clinical isolates of MRAB in the outbreak setting. Findings: Of 11 highly care-dependent patients with 363 MRAB colonization days during COVID-19 pandemic, 10 (90.9%) and nine (81.8%) had cutaneous and gastrointestinal colonization, respectively. Of 160 environmental and air samples, 31 (19.4%) were MRAB-positive. The proportion of MRAB-contaminated commonly shared items was significantly lower in cohort than in non-cohort patient care (0/10, 0% vs 12/18, 66.7%; P<0.001). Air dispersal of MRAB was consistently detected during but not before diaper change in the cohort cubicle by 25-min air sampling (4/4,100% vs 0/4, 0%; P=0.029). The settle plate method revealed MRAB in two samples during diaper change. The proportion of MRAB-contaminated exhaust air grills was significantly higher when the cohort cubicle was occupied by six MRAB patients than when fewer than six patients were cared for in the cubicle (5/9, 55.6% vs 0/18, 0%; P=0.002). The proportion of MRAB-contaminated non-reachable high-level surfaces was also significantly higher when there were three or more MRAB patients in the cohort cubicle (8/31, 25.8% vs 0/24, 0%; P=0.016). Whole-genome sequencing revealed clonality of air, environment, and patients' isolates, suggestive of air dispersal of MRAB. Conclusions: Our findings support the view that patient cohorting in enclosed cubicles with partitions and a closed door is preferred if single rooms are not available.-
dc.languageeng-
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin-
dc.relation.ispartofJournal of Hospital Infection-
dc.subjectAir-
dc.subjectmultidrug-resistant-
dc.subjectAcinetobacter baumannii-
dc.subjectnosocomial-
dc.subjectCOVID-19-
dc.titleAir dispersal of multidrug-resistant Acinetobacter baumannii: implications for nosocomial transmission during the COVID-19 pandemic-
dc.typeArticle-
dc.identifier.emailWong, SC: shchwong@hku.hk-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailLi, X: xinli@hku.hk-
dc.identifier.emailChan, VWM: mbally@hku.hk-
dc.identifier.emailHo, PL: plho@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityLi, X=rp02808-
dc.identifier.authorityHo, PL=rp00406-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jhin.2021.08.005-
dc.identifier.pmid34403765-
dc.identifier.pmcidPMC8429036-
dc.identifier.scopuseid_2-s2.0-85114696353-
dc.identifier.hkuros325624-
dc.identifier.volume116-
dc.identifier.spage78-
dc.identifier.epage86-
dc.identifier.isiWOS:000702715000011-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats