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- Publisher Website: 10.1080/22221751.2021.1976598
- Scopus: eid_2-s2.0-85115211855
- PMID: 34490832
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Article: SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications
Title | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
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Authors | |
Keywords | SARS-CoV-2 Non-human primates Severe acute respiratory syndrome Immunopathogenesis Vaccine and drug discovery |
Issue Date | 2021 |
Publisher | Taylor & Francis, published in association with Shanghai Shangyixun Cultural Communication Company. The Journal's web site is located at https://www.tandfonline.com/toc/temi20/current |
Citation | Emerging Microbes & Infections, 2021, v. 10 n. 1, p. 1881-1889 How to Cite? |
Abstract | SARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that the non-human primate (NHP) is permissive for SARS-CoV-2 infection to cause typical clinical symptoms including fever, cough, breathing difficulty, and other diagnostic abnormalities such as immunopathogenesis and hyperplastic lesions in the lung. These NHP models have been used for investigating the potential infection route and host immune response to SARS-CoV-2, as well as testing vaccines and drugs. This review aims to summarize the benefits and caveats of NHP models currently available for SARS-CoV-2, and to discuss key topics including model optimization, extended application, and clinical translation. |
Persistent Identifier | http://hdl.handle.net/10722/304166 |
ISSN | 2021 Impact Factor: 19.568 2020 SCImago Journal Rankings: 2.475 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yuan, L | - |
dc.contributor.author | Tang, Q | - |
dc.contributor.author | Zhu, H | - |
dc.contributor.author | Guan, Y | - |
dc.contributor.author | Cheng, T | - |
dc.contributor.author | Xia, N | - |
dc.date.accessioned | 2021-09-23T08:56:09Z | - |
dc.date.available | 2021-09-23T08:56:09Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Emerging Microbes & Infections, 2021, v. 10 n. 1, p. 1881-1889 | - |
dc.identifier.issn | 2222-1751 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304166 | - |
dc.description.abstract | SARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that the non-human primate (NHP) is permissive for SARS-CoV-2 infection to cause typical clinical symptoms including fever, cough, breathing difficulty, and other diagnostic abnormalities such as immunopathogenesis and hyperplastic lesions in the lung. These NHP models have been used for investigating the potential infection route and host immune response to SARS-CoV-2, as well as testing vaccines and drugs. This review aims to summarize the benefits and caveats of NHP models currently available for SARS-CoV-2, and to discuss key topics including model optimization, extended application, and clinical translation. | - |
dc.language | eng | - |
dc.publisher | Taylor & Francis, published in association with Shanghai Shangyixun Cultural Communication Company. The Journal's web site is located at https://www.tandfonline.com/toc/temi20/current | - |
dc.relation.ispartof | Emerging Microbes & Infections | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | Non-human primates | - |
dc.subject | Severe acute respiratory syndrome | - |
dc.subject | Immunopathogenesis | - |
dc.subject | Vaccine and drug discovery | - |
dc.title | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications | - |
dc.type | Article | - |
dc.identifier.email | Zhu, H: zhuhch@hku.hk | - |
dc.identifier.email | Guan, Y: yguan@hkucc.hku.hk | - |
dc.identifier.authority | Zhu, H=rp01535 | - |
dc.identifier.authority | Guan, Y=rp00397 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1080/22221751.2021.1976598 | - |
dc.identifier.pmid | 34490832 | - |
dc.identifier.pmcid | PMC8451603 | - |
dc.identifier.scopus | eid_2-s2.0-85115211855 | - |
dc.identifier.hkuros | 325410 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1881 | - |
dc.identifier.epage | 1889 | - |
dc.identifier.isi | WOS:000697179700001 | - |
dc.publisher.place | United Kingdom | - |