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Article: Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

TitleGender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster
Authors
Issue Date2021
Citation
Signal Transduction and Targeted Therapy, 2021, v. 6 How to Cite?
Abstractpidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss, weakness, piloerection, hunched back and abdominal respiration, as well as severe pneumonia, pulmonary edema, consolidation, and fibrosis. In contrast with the males, the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis. The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.
Persistent Identifierhttp://hdl.handle.net/10722/304168

 

DC FieldValueLanguage
dc.contributor.authorYuan, L-
dc.contributor.authorZhu, H-
dc.contributor.authorZhou, M-
dc.contributor.authorMa, J-
dc.contributor.authorChen, R-
dc.contributor.authorChen, Y-
dc.contributor.authorChen, L-
dc.contributor.authorWu, K-
dc.contributor.authorCai, M-
dc.contributor.authorHong, J-
dc.contributor.authorLi, L-
dc.contributor.authorLiu, C-
dc.contributor.authorYu, H-
dc.contributor.authorZhang, Y-
dc.contributor.authorWang, J-
dc.contributor.authorZhang, T-
dc.contributor.authorGe, S-
dc.contributor.authorZhang, J-
dc.contributor.authorYuan, Q-
dc.contributor.authorChen, Y-
dc.contributor.authorTang, Q-
dc.contributor.authorChen, H-
dc.contributor.authorCheng, T-
dc.contributor.authorGuan, Y-
dc.contributor.authorXia, N-
dc.date.accessioned2021-09-23T08:56:10Z-
dc.date.available2021-09-23T08:56:10Z-
dc.date.issued2021-
dc.identifier.citationSignal Transduction and Targeted Therapy, 2021, v. 6-
dc.identifier.urihttp://hdl.handle.net/10722/304168-
dc.description.abstractpidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss, weakness, piloerection, hunched back and abdominal respiration, as well as severe pneumonia, pulmonary edema, consolidation, and fibrosis. In contrast with the males, the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis. The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.-
dc.languageeng-
dc.relation.ispartofSignal Transduction and Targeted Therapy-
dc.titleGender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster-
dc.typeArticle-
dc.identifier.emailZhu, H: zhuhch@hku.hk-
dc.identifier.emailLi, L: lifeng@hkucc.hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authorityZhu, H=rp01535-
dc.identifier.authorityGuan, Y=rp00397-
dc.identifier.doi10.1038/s41392-021-00552-0-
dc.identifier.hkuros325421-
dc.identifier.volume6-

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