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Article: Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

TitleGender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/sigtrans/
Citation
Signal Transduction and Targeted Therapy, 2021, v. 6, article no. 136 How to Cite?
AbstractEpidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss, weakness, piloerection, hunched back and abdominal respiration, as well as severe pneumonia, pulmonary edema, consolidation, and fibrosis. In contrast with the males, the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis. The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.
Persistent Identifierhttp://hdl.handle.net/10722/304168
ISSN
2023 Impact Factor: 40.8
2023 SCImago Journal Rankings: 8.737
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, L-
dc.contributor.authorZhu, H-
dc.contributor.authorZhou, M-
dc.contributor.authorMa, J-
dc.contributor.authorChen, R-
dc.contributor.authorChen, Y-
dc.contributor.authorChen, L-
dc.contributor.authorWu, K-
dc.contributor.authorCai, M-
dc.contributor.authorHong, J-
dc.contributor.authorLi, L-
dc.contributor.authorLiu, C-
dc.contributor.authorYu, H-
dc.contributor.authorZhang, Y-
dc.contributor.authorWang, J-
dc.contributor.authorZhang, T-
dc.contributor.authorGe, S-
dc.contributor.authorZhang, J-
dc.contributor.authorYuan, Q-
dc.contributor.authorChen, Y-
dc.contributor.authorTang, Q-
dc.contributor.authorChen, H-
dc.contributor.authorCheng, T-
dc.contributor.authorGuan, Y-
dc.contributor.authorXia, N-
dc.date.accessioned2021-09-23T08:56:10Z-
dc.date.available2021-09-23T08:56:10Z-
dc.date.issued2021-
dc.identifier.citationSignal Transduction and Targeted Therapy, 2021, v. 6, article no. 136-
dc.identifier.issn2059-3635-
dc.identifier.urihttp://hdl.handle.net/10722/304168-
dc.description.abstractEpidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2. Remarkably, high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss, weakness, piloerection, hunched back and abdominal respiration, as well as severe pneumonia, pulmonary edema, consolidation, and fibrosis. In contrast with the males, the female hamsters showed much lower shedding viral titers, moderate symptoms, and relatively mild lung pathogenesis. The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/sigtrans/-
dc.relation.ispartofSignal Transduction and Targeted Therapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleGender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster-
dc.typeArticle-
dc.identifier.emailZhu, H: zhuhch@hku.hk-
dc.identifier.emailLi, L: lifeng@hkucc.hku.hk-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authorityZhu, H=rp01535-
dc.identifier.authorityChen, H=rp00383-
dc.identifier.authorityGuan, Y=rp00397-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41392-021-00552-0-
dc.identifier.pmid33790236-
dc.identifier.pmcidPMC8009924-
dc.identifier.scopuseid_2-s2.0-85103744471-
dc.identifier.hkuros325421-
dc.identifier.volume6-
dc.identifier.spagearticle no. 136-
dc.identifier.epagearticle no. 136-
dc.identifier.isiWOS:000636369600001-
dc.publisher.placeUnited States-

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