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- Publisher Website: 10.1111/bjh.17316
- Scopus: eid_2-s2.0-85100489719
- PMID: 33481245
- WOS: WOS:000609933200001
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Article: Poor mobilization of autologous CD34+ peripheral blood stem cells in haematology patients undergoing autologous stem cell transplantation is associated with the presence of variants in genes implicated in clonal haematopoiesis of indeterminant potential
Title | Poor mobilization of autologous CD34+ peripheral blood stem cells in haematology patients undergoing autologous stem cell transplantation is associated with the presence of variants in genes implicated in clonal haematopoiesis of indeterminant potential |
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Authors | |
Keywords | clonality haematopoietic stem cells molecular stem cell mobilization/homing |
Issue Date | 2021 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH |
Citation | British Journal of Haematology, 2021, v. 193 n. 4, p. 841-844 How to Cite? |
Abstract | Clonal haematopoiesis of indeterminant potential (CHIP) increases in frequency with age. The effect of CHIP on the mobilization of autologous CD34+ peripheral blood stem cells (PBSC) has not been reported. This study uses a DNA-based targeted candidate gene approach to identify the presence of somatic mutations in ASXL1, DNMT3A, JAK2, SF3B1, TET2 and TP53 in CD34+ haematopoietic progenitor cell-apheresis products of 96 patients who undergo PBSC mobilization for autologous stem cell transplantation (ASCT). Variants were identified in a significantly greater proportion of patients who experience poor CD34+ PBSC mobilization. A DNA-based targeted candidate gene array is able to predict poor CD34+ PBSC mobilization and may be deployed pre-emptively to minimize mobilization and graft failures. |
Persistent Identifier | http://hdl.handle.net/10722/304559 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.574 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gifford, G | - |
dc.contributor.author | Hesson, L | - |
dc.contributor.author | Wong, JWH | - |
dc.contributor.author | Carroll, A | - |
dc.contributor.author | Gabrielli, S | - |
dc.contributor.author | Bai, L | - |
dc.contributor.author | Xia, W | - |
dc.contributor.author | Stevenson, W | - |
dc.contributor.author | Greenwood, M | - |
dc.date.accessioned | 2021-09-23T09:01:47Z | - |
dc.date.available | 2021-09-23T09:01:47Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | British Journal of Haematology, 2021, v. 193 n. 4, p. 841-844 | - |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304559 | - |
dc.description.abstract | Clonal haematopoiesis of indeterminant potential (CHIP) increases in frequency with age. The effect of CHIP on the mobilization of autologous CD34+ peripheral blood stem cells (PBSC) has not been reported. This study uses a DNA-based targeted candidate gene approach to identify the presence of somatic mutations in ASXL1, DNMT3A, JAK2, SF3B1, TET2 and TP53 in CD34+ haematopoietic progenitor cell-apheresis products of 96 patients who undergo PBSC mobilization for autologous stem cell transplantation (ASCT). Variants were identified in a significantly greater proportion of patients who experience poor CD34+ PBSC mobilization. A DNA-based targeted candidate gene array is able to predict poor CD34+ PBSC mobilization and may be deployed pre-emptively to minimize mobilization and graft failures. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH | - |
dc.relation.ispartof | British Journal of Haematology | - |
dc.rights | Submitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | clonality | - |
dc.subject | haematopoietic stem cells | - |
dc.subject | molecular | - |
dc.subject | stem cell mobilization/homing | - |
dc.title | Poor mobilization of autologous CD34+ peripheral blood stem cells in haematology patients undergoing autologous stem cell transplantation is associated with the presence of variants in genes implicated in clonal haematopoiesis of indeterminant potential | - |
dc.type | Article | - |
dc.identifier.email | Wong, JWH: jwhwong@hku.hk | - |
dc.identifier.authority | Wong, JWH=rp02363 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/bjh.17316 | - |
dc.identifier.pmid | 33481245 | - |
dc.identifier.scopus | eid_2-s2.0-85100489719 | - |
dc.identifier.hkuros | 325654 | - |
dc.identifier.volume | 193 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 841 | - |
dc.identifier.epage | 844 | - |
dc.identifier.isi | WOS:000609933200001 | - |
dc.publisher.place | United Kingdom | - |