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- Publisher Website: 10.1016/j.bone.2021.116015
- Scopus: eid_2-s2.0-85106563967
- PMID: 34029778
- WOS: WOS:000670351300004
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Article: The association between blood pressure variability and hip or vertebral fracture risk: A population-based study
Title | The association between blood pressure variability and hip or vertebral fracture risk: A population-based study |
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Authors | |
Keywords | Hip fracture Vertebral fracture Blood pressure variability Association |
Issue Date | 2021 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone |
Citation | Bone, 2021, v. 150, article no. 116015 How to Cite? |
Abstract | Background:
The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients.
Methods:
This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures.
Results:
A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001).
Conclusions:
Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification. |
Persistent Identifier | http://hdl.handle.net/10722/304694 |
ISSN | 2021 Impact Factor: 4.626 2020 SCImago Journal Rankings: 1.346 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhou, J | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Chang, C | - |
dc.contributor.author | Wu, WKK | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Liu, T | - |
dc.contributor.author | Cheung, BMY | - |
dc.contributor.author | Zhang, Q | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Tse, G | - |
dc.date.accessioned | 2021-10-05T02:33:48Z | - |
dc.date.available | 2021-10-05T02:33:48Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Bone, 2021, v. 150, article no. 116015 | - |
dc.identifier.issn | 8756-3282 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304694 | - |
dc.description.abstract | Background: The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients. Methods: This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures. Results: A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001). Conclusions: Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone | - |
dc.relation.ispartof | Bone | - |
dc.subject | Hip fracture | - |
dc.subject | Vertebral fracture | - |
dc.subject | Blood pressure variability | - |
dc.subject | Association | - |
dc.title | The association between blood pressure variability and hip or vertebral fracture risk: A population-based study | - |
dc.type | Article | - |
dc.identifier.email | Cheung, BMY: mycheung@hkucc.hku.hk | - |
dc.identifier.authority | Cheung, BMY=rp01321 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bone.2021.116015 | - |
dc.identifier.pmid | 34029778 | - |
dc.identifier.scopus | eid_2-s2.0-85106563967 | - |
dc.identifier.hkuros | 326203 | - |
dc.identifier.volume | 150 | - |
dc.identifier.spage | article no. 116015 | - |
dc.identifier.epage | article no. 116015 | - |
dc.identifier.isi | WOS:000670351300004 | - |
dc.publisher.place | United States | - |