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Article: 2D MOF Periodontitis Photodynamic Ion Therapy

Title2D MOF Periodontitis Photodynamic Ion Therapy
Authors
Issue Date2021
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal of the American Chemical Society, 2021, v. 143 n. 37, p. 15427-15439 How to Cite?
AbstractTraditional surgical intervention and antibiotic treatment are poor and even invalid for chronic diseases including periodontitis induced by diverse oral pathogens, which often causes progressive destruction of tissues, even tooth loss, and systemic diseases. Herein, an ointment comprising atomic-layer Fe2O3-modified two-dimensional porphyrinic metal–organic framework (2D MOF) nanosheets is designed by incorporating a polyethylene glycol matrix. After the atomic layer deposition surface engineering, the enhanced photocatalytic activity of the 2D MOF heterointerface results from lower adsorption energy and more charge transfer amounts due to the synergistic effect of metal–linker bridging units, abundant active sites, and an excellent light-harvesting network. This biocompatible and biodegradable 2D MOF-based heterostructure exhibits broad-spectrum antimicrobial activity (99.87 ± 0.09%, 99.57 ± 0.21%, and 99.03 ± 0.24%) against diverse oral pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Staphylococcus aureus) by the synergistic effect of reactive oxygen species and released ions. This photodynamic ion therapy exhibits a superior therapeutic effect to the reported clinical periodontitis treatment owing to rapid antibacterial activity, alleviative inflammation, and improved angiogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/304728
ISSN
2020 Impact Factor: 15.419
2020 SCImago Journal Rankings: 7.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLI, J-
dc.contributor.authorSONG, S-
dc.contributor.authorMENG, J-
dc.contributor.authorTAN, L-
dc.contributor.authorLIU, X-
dc.contributor.authorZHENG, Y-
dc.contributor.authorLI, Z-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCUI, Z-
dc.contributor.authorLIANG, Y-
dc.contributor.authorZHU, S-
dc.contributor.authorZHANG, X-
dc.contributor.authorWU, S-
dc.date.accessioned2021-10-05T02:34:19Z-
dc.date.available2021-10-05T02:34:19Z-
dc.date.issued2021-
dc.identifier.citationJournal of the American Chemical Society, 2021, v. 143 n. 37, p. 15427-15439-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/304728-
dc.description.abstractTraditional surgical intervention and antibiotic treatment are poor and even invalid for chronic diseases including periodontitis induced by diverse oral pathogens, which often causes progressive destruction of tissues, even tooth loss, and systemic diseases. Herein, an ointment comprising atomic-layer Fe2O3-modified two-dimensional porphyrinic metal–organic framework (2D MOF) nanosheets is designed by incorporating a polyethylene glycol matrix. After the atomic layer deposition surface engineering, the enhanced photocatalytic activity of the 2D MOF heterointerface results from lower adsorption energy and more charge transfer amounts due to the synergistic effect of metal–linker bridging units, abundant active sites, and an excellent light-harvesting network. This biocompatible and biodegradable 2D MOF-based heterostructure exhibits broad-spectrum antimicrobial activity (99.87 ± 0.09%, 99.57 ± 0.21%, and 99.03 ± 0.24%) against diverse oral pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Staphylococcus aureus) by the synergistic effect of reactive oxygen species and released ions. This photodynamic ion therapy exhibits a superior therapeutic effect to the reported clinical periodontitis treatment owing to rapid antibacterial activity, alleviative inflammation, and improved angiogenesis.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html-
dc.relation.ispartofJournal of the American Chemical Society-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.title2D MOF Periodontitis Photodynamic Ion Therapy-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jacs.1c07875-
dc.identifier.pmid34516125-
dc.identifier.scopuseid_2-s2.0-85116053029-
dc.identifier.hkuros326135-
dc.identifier.volume143-
dc.identifier.issue37-
dc.identifier.spage15427-
dc.identifier.epage15439-
dc.identifier.isiWOS:000700883200056-
dc.publisher.placeUnited States-

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