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Article: Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific
Title | Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific |
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Authors | |
Keywords | primary immunodeficiencies resource needs health resources immunology standard of care |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology |
Citation | Frontiers in Immunology, 2020, v. 11, p. article no. 1605 How to Cite? |
Abstract | Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training.
Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan.
Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation.
Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently.
Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research. |
Persistent Identifier | http://hdl.handle.net/10722/304741 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.868 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LEUNG, D | - |
dc.contributor.author | Chua, GT | - |
dc.contributor.author | Mondragon, AV | - |
dc.contributor.author | Zhong, Y | - |
dc.contributor.author | Nguyen-Ngo-Quynh, L | - |
dc.contributor.author | Imai, K | - |
dc.contributor.author | Vignesh, P | - |
dc.contributor.author | Suratannon, N | - |
dc.contributor.author | Mao, H | - |
dc.contributor.author | Lee, WI | - |
dc.contributor.author | Kim, YJ | - |
dc.contributor.author | Chan, GCF | - |
dc.contributor.author | Liew, WK | - |
dc.contributor.author | Huong, LTM | - |
dc.contributor.author | Kanegane, H | - |
dc.contributor.author | Muktiarti, D | - |
dc.contributor.author | Zhao, X | - |
dc.contributor.author | Santos-Ocampo, FJ | - |
dc.contributor.author | Latiff, AHA | - |
dc.contributor.author | Seger, R | - |
dc.contributor.author | Ochs, HD | - |
dc.contributor.author | Singh, S | - |
dc.contributor.author | Lee, PP | - |
dc.contributor.author | Lau, YL | - |
dc.date.accessioned | 2021-10-05T02:34:30Z | - |
dc.date.available | 2021-10-05T02:34:30Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Immunology, 2020, v. 11, p. article no. 1605 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304741 | - |
dc.description.abstract | Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training. Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan. Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation. Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently. Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology | - |
dc.relation.ispartof | Frontiers in Immunology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | primary immunodeficiencies | - |
dc.subject | resource needs | - |
dc.subject | health resources | - |
dc.subject | immunology | - |
dc.subject | standard of care | - |
dc.title | Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific | - |
dc.type | Article | - |
dc.identifier.email | Chua, GT: cgt560@hku.hk | - |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | - |
dc.identifier.email | Lee, PP: ppwlee@hku.hk | - |
dc.identifier.email | Lau, YL: lauylung@hku.hk | - |
dc.identifier.authority | Chua, GT=rp02684 | - |
dc.identifier.authority | Chan, GCF=rp00431 | - |
dc.identifier.authority | Lee, PP=rp00462 | - |
dc.identifier.authority | Lau, YL=rp00361 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fimmu.2020.01605 | - |
dc.identifier.pmid | 32903579 | - |
dc.identifier.pmcid | PMC7438539 | - |
dc.identifier.scopus | eid_2-s2.0-85089887512 | - |
dc.identifier.hkuros | 326311 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 1605 | - |
dc.identifier.epage | article no. 1605 | - |
dc.identifier.isi | WOS:000565982800001 | - |
dc.publisher.place | Switzerland | - |