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Article: The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

TitleThe metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 3073 How to Cite?
AbstractFollicular helper T (TFH) cells control antibody responses by supporting antibody affinity maturation and memory formation. Inadequate TFH function has been found in individuals with ineffective responses to vaccines, but the mechanism underlying TFH regulation in vaccination is not understood. Here, we report that lower serum levels of the metabolic hormone leptin associate with reduced vaccine responses to influenza or hepatitis B virus vaccines in healthy populations. Leptin promotes mouse and human TFH differentiation and IL-21 production via STAT3 and mTOR pathways. Leptin receptor deficiency impairs TFH generation and antibody responses in immunisation and infection. Similarly, leptin deficiency induced by fasting reduces influenza vaccination-mediated protection for the subsequent infection challenge, which is mostly rescued by leptin replacement. Our results identify leptin as a regulator of TFH cell differentiation and function and indicate low levels of leptin as a risk factor for vaccine failure.
Persistent Identifierhttp://hdl.handle.net/10722/304804
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDeng, J-
dc.contributor.authorChen, Q-
dc.contributor.authorChen, Z-
dc.contributor.authorLiang, K-
dc.contributor.authorGao, X-
dc.contributor.authorWang, X-
dc.contributor.authorMakota, FV-
dc.contributor.authorOng, HS-
dc.contributor.authorWan, Y-
dc.contributor.authorLuo, K-
dc.contributor.authorGong, D-
dc.contributor.authorYu, X-
dc.contributor.authorCamulia, S-
dc.contributor.authorZeng, Q-
dc.contributor.authorZhou, T-
dc.contributor.authorXue, F-
dc.contributor.authorHe, J-
dc.contributor.authorWei, Y-
dc.contributor.authorXiao, F-
dc.contributor.authorMa, J-
dc.contributor.authorHill, DL-
dc.contributor.authorPierson, W-
dc.contributor.authorNguyen, THO-
dc.contributor.authorZhou, H-
dc.contributor.authorWang, Y-
dc.contributor.authorShen, W-
dc.contributor.authorSun, W-
dc.contributor.authorLi, Z-
dc.contributor.authorXia, Q-
dc.contributor.authorQian, K-
dc.contributor.authorYe, L-
dc.contributor.authorRockman, S-
dc.contributor.authorLinterman, MA-
dc.contributor.authorKedzierska, K-
dc.contributor.authorShen, N-
dc.contributor.authorLu, L-
dc.contributor.authorYu, D-
dc.date.accessioned2021-10-05T02:35:26Z-
dc.date.available2021-10-05T02:35:26Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 3073-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/304804-
dc.description.abstractFollicular helper T (TFH) cells control antibody responses by supporting antibody affinity maturation and memory formation. Inadequate TFH function has been found in individuals with ineffective responses to vaccines, but the mechanism underlying TFH regulation in vaccination is not understood. Here, we report that lower serum levels of the metabolic hormone leptin associate with reduced vaccine responses to influenza or hepatitis B virus vaccines in healthy populations. Leptin promotes mouse and human TFH differentiation and IL-21 production via STAT3 and mTOR pathways. Leptin receptor deficiency impairs TFH generation and antibody responses in immunisation and infection. Similarly, leptin deficiency induced by fasting reduces influenza vaccination-mediated protection for the subsequent infection challenge, which is mostly rescued by leptin replacement. Our results identify leptin as a regulator of TFH cell differentiation and function and indicate low levels of leptin as a risk factor for vaccine failure.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleThe metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses-
dc.typeArticle-
dc.identifier.emailWang, X: xiaohuiwang@hku.hk-
dc.identifier.emailXiao, F: xiaof@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityWang, X=rp02664-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-23220-x-
dc.identifier.pmid34031386-
dc.identifier.pmcidPMC8144586-
dc.identifier.scopuseid_2-s2.0-85106588847-
dc.identifier.hkuros326218-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 3073-
dc.identifier.epagearticle no. 3073-
dc.identifier.isiWOS:000658769900025-
dc.publisher.placeUnited Kingdom-

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