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Conference Paper: MASS SCREENING AND THE LOW RATES OF ACUTE KIDNEY INJURY AMONG COVID-19 PATIENTS IN HONG KONG

TitleMASS SCREENING AND THE LOW RATES OF ACUTE KIDNEY INJURY AMONG COVID-19 PATIENTS IN HONG KONG
Authors
Issue Date2021
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
The 58th European Renal Association - European Dialysis and Transplant Association (ERA- EDTA) Congress, Virtual Meeting, 5–8 June 2021. In Nephrology Dialysis Transplantation, 2021, v. 36 n. Suppl. 1, p. 161, abstract no. MO386 How to Cite?
AbstractBackground and Aims: Renal involvement in COVID-19 under vigilant public health surveillance, including mass screening and early hospitalization is less well-characterized. We assessed renal involvement of COVID-19 patients in Hong Kong, including the association with risk factors, length of hospitalization, critical presentation and mortality. Method: Linked electronic records of all confirmed patients from 5 major designated hospitals were extracted. Primary outcome was the incidence of in-hospital AKI. Secondary outcomes were AKI-associated mortality, incident RRT, intensive care admission, prolonged hospitalization and disease course (defined as >90th percentile of hospitalization duration and duration from symptom onset to discharge, respectively), and change of eGFR. Patients were further stratified into being symptomatic or asymptomatic. Results: Patients were characterized by young age (median:38.4, IQR:28.4-55.8 years old) and short time (Median:5, IQR:2-9 days) from symptom onset to admission. Among the 591 patients, 22 (3.72%) developed AKI and 4 (0.68%) required RRT. AKI increased the odds of prolonged hospitalization and disease course by 2.0 and 3.5 folds, respectively. Estimated GFR 24 weeks post-discharge reduced by 7.51 and 1.06 ml/min/1.73m2 versus baseline (at admission) in the AKI and non-AKI groups, respectively. The incidence of AKI was comparable between asymptomatic (4.8%) and symptomatic (3.7%) patients. Conclusion: The overall rate of AKI among COVID-19 patients in Hong Kong is low, which could be attributable to a vigilant screening program and early hospitalization. Among patients who developed in-hospital AKI, the duration of hospitalization is prolonged and kidney function impairment can persist for up to 6 months post-discharge. Mass surveillance for COVID-19 is warranted in identifying asymptomatic subjects for earlier AKI management.
Persistent Identifierhttp://hdl.handle.net/10722/304814
ISSN
2020 Impact Factor: 5.992
2020 SCImago Journal Rankings: 1.654

 

DC FieldValueLanguage
dc.contributor.authorChan, KW-
dc.contributor.authorHung, FNI-
dc.contributor.authorTsang, OT-
dc.contributor.authorWu, TC-
dc.contributor.authorTso, Y-
dc.contributor.authorLung, KC-
dc.contributor.authorLam, CM-
dc.contributor.authorChan, GCW-
dc.contributor.authorWong, SSH-
dc.contributor.authorYu, KY-
dc.contributor.authorChan, JW-
dc.contributor.authorTang, SCW-
dc.date.accessioned2021-10-05T02:35:35Z-
dc.date.available2021-10-05T02:35:35Z-
dc.date.issued2021-
dc.identifier.citationThe 58th European Renal Association - European Dialysis and Transplant Association (ERA- EDTA) Congress, Virtual Meeting, 5–8 June 2021. In Nephrology Dialysis Transplantation, 2021, v. 36 n. Suppl. 1, p. 161, abstract no. MO386-
dc.identifier.issn0931-0509-
dc.identifier.urihttp://hdl.handle.net/10722/304814-
dc.description.abstractBackground and Aims: Renal involvement in COVID-19 under vigilant public health surveillance, including mass screening and early hospitalization is less well-characterized. We assessed renal involvement of COVID-19 patients in Hong Kong, including the association with risk factors, length of hospitalization, critical presentation and mortality. Method: Linked electronic records of all confirmed patients from 5 major designated hospitals were extracted. Primary outcome was the incidence of in-hospital AKI. Secondary outcomes were AKI-associated mortality, incident RRT, intensive care admission, prolonged hospitalization and disease course (defined as >90th percentile of hospitalization duration and duration from symptom onset to discharge, respectively), and change of eGFR. Patients were further stratified into being symptomatic or asymptomatic. Results: Patients were characterized by young age (median:38.4, IQR:28.4-55.8 years old) and short time (Median:5, IQR:2-9 days) from symptom onset to admission. Among the 591 patients, 22 (3.72%) developed AKI and 4 (0.68%) required RRT. AKI increased the odds of prolonged hospitalization and disease course by 2.0 and 3.5 folds, respectively. Estimated GFR 24 weeks post-discharge reduced by 7.51 and 1.06 ml/min/1.73m2 versus baseline (at admission) in the AKI and non-AKI groups, respectively. The incidence of AKI was comparable between asymptomatic (4.8%) and symptomatic (3.7%) patients. Conclusion: The overall rate of AKI among COVID-19 patients in Hong Kong is low, which could be attributable to a vigilant screening program and early hospitalization. Among patients who developed in-hospital AKI, the duration of hospitalization is prolonged and kidney function impairment can persist for up to 6 months post-discharge. Mass surveillance for COVID-19 is warranted in identifying asymptomatic subjects for earlier AKI management.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/-
dc.relation.ispartofNephrology Dialysis Transplantation-
dc.relation.ispartofThe 58th European Renal Association - European Dialysis and Transplant Association (ERA- EDTA) Congress-
dc.titleMASS SCREENING AND THE LOW RATES OF ACUTE KIDNEY INJURY AMONG COVID-19 PATIENTS IN HONG KONG-
dc.typeConference_Paper-
dc.identifier.emailChan, KW: chriskwc@hku.hk-
dc.identifier.emailHung, FNI: ivanhung@hkucc.hku.hk-
dc.identifier.emailYu, KY: karenkyy@hku.hk-
dc.identifier.emailTang, SCW: scwtang@hku.hk-
dc.identifier.authorityHung, FNI=rp00508-
dc.identifier.authorityTang, SCW=rp00480-
dc.description.natureabstract-
dc.identifier.doi10.1093/ndt/gfab082.0040-
dc.identifier.hkuros326411-
dc.identifier.volume36-
dc.identifier.issueSuppl. 1-
dc.identifier.spage161, abstract no. MO386-
dc.identifier.epage161, abstract no. MO386-
dc.publisher.placeUnited Kingdom-

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