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Article: Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases

TitleLineage-specific protection and immune imprinting shape the age distributions of influenza B cases
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 4313 How to Cite?
AbstractHow a history of influenza virus infections contributes to protection is not fully understood, but such protection might explain the contrasting age distributions of cases of the two lineages of influenza B, B/Victoria and B/Yamagata. Fitting a statistical model to those distributions using surveillance data from New Zealand, we found they could be explained by historical changes in lineage frequencies combined with cross-protection between strains of the same lineage. We found additional protection against B/Yamagata in people for whom it was their first influenza B infection, similar to the immune imprinting observed in influenza A. While the data were not informative about B/Victoria imprinting, B/Yamagata imprinting could explain the fewer B/Yamagata than B/Victoria cases in cohorts born in the 1990s and the bimodal age distribution of B/Yamagata cases. Longitudinal studies can test if these forms of protection inferred from historical data extend to more recent strains and other populations.
Persistent Identifierhttp://hdl.handle.net/10722/304877
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVieira, MC-
dc.contributor.authorDonato, CM-
dc.contributor.authorArevalo, P-
dc.contributor.authorRimmelzwaan, GF-
dc.contributor.authorWood, T-
dc.contributor.authorLoopez, L-
dc.contributor.authorHuang, QS-
dc.contributor.authorDhanasekaran, V-
dc.contributor.authorKoelle, K-
dc.contributor.authorCobey, S-
dc.date.accessioned2021-10-05T02:36:30Z-
dc.date.available2021-10-05T02:36:30Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 4313-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/304877-
dc.description.abstractHow a history of influenza virus infections contributes to protection is not fully understood, but such protection might explain the contrasting age distributions of cases of the two lineages of influenza B, B/Victoria and B/Yamagata. Fitting a statistical model to those distributions using surveillance data from New Zealand, we found they could be explained by historical changes in lineage frequencies combined with cross-protection between strains of the same lineage. We found additional protection against B/Yamagata in people for whom it was their first influenza B infection, similar to the immune imprinting observed in influenza A. While the data were not informative about B/Victoria imprinting, B/Yamagata imprinting could explain the fewer B/Yamagata than B/Victoria cases in cohorts born in the 1990s and the bimodal age distribution of B/Yamagata cases. Longitudinal studies can test if these forms of protection inferred from historical data extend to more recent strains and other populations.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleLineage-specific protection and immune imprinting shape the age distributions of influenza B cases-
dc.typeArticle-
dc.identifier.emailDhanasekaran, V: veej@hku.hk-
dc.identifier.authorityDhanasekaran, V=rp02721-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-24566-y-
dc.identifier.pmid34262041-
dc.identifier.pmcidPMC8280188-
dc.identifier.scopuseid_2-s2.0-85110784213-
dc.identifier.hkuros325814-
dc.identifier.hkuros317399-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 4313-
dc.identifier.epagearticle no. 4313-
dc.identifier.isiWOS:000675629500001-
dc.publisher.placeUnited Kingdom-

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