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Article: SARS-CoV-2 under an elimination strategy in Hong Kong

TitleSARS-CoV-2 under an elimination strategy in Hong Kong
Authors
Gu, HXIE, RAdam, DCTsui, JLHChu, DKChang, LDJCheuk, SSYGURUNG, SGKrishnan, PNg, DYMLiu, GYZWan, KCEdwards, KMLeung, KSMWu, JTTsang, DNCLeung, GMCowling, BJPeiris, MLam, TTYDhanasekaran, VPoon, LLM
Issue Date2021
PublisherCold Spring Harbor Laboratory. The Journal's web site is located at https://www.medrxiv.org/
Citation
medRxiv: the Preprint for Health Sciences, 2021, June 23 How to Cite?
DOI: http://dx.doi.org/10.1101/2021.06.19.21259169
AbstractHong Kong utilized an elimination strategy with intermittent use of public health and social measures and increasingly stringent travel regulations to control SARS-CoV-2 transmission. By analyzing >1700 genome sequences representing 17% of confirmed cases from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases, two of which circulated cryptically for weeks while less stringent measures were in place. We found that SARS-CoV-2 within-host diversity was most similar among transmission pairs and epidemiological clusters due to a strong transmission bottleneck through which similar genetic background generates similar within-host diversity.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/304882

 

DC FieldValueLanguage
dc.contributor.authorGu, H-
dc.contributor.authorXIE, R-
dc.contributor.authorAdam, DC-
dc.contributor.authorTsui, JLH-
dc.contributor.authorChu, DK-
dc.contributor.authorChang, LDJ-
dc.contributor.authorCheuk, SSY-
dc.contributor.authorGURUNG, SG-
dc.contributor.authorKrishnan, P-
dc.contributor.authorNg, DYM-
dc.contributor.authorLiu, GYZ-
dc.contributor.authorWan, KC-
dc.contributor.authorEdwards, KM-
dc.contributor.authorLeung, KSM-
dc.contributor.authorWu, JT-
dc.contributor.authorTsang, DNC-
dc.contributor.authorLeung, GM-
dc.contributor.authorCowling, BJ-
dc.contributor.authorPeiris, M-
dc.contributor.authorLam, TTY-
dc.contributor.authorDhanasekaran, V-
dc.contributor.authorPoon, LLM-
dc.date.accessioned2021-10-05T02:36:34Z-
dc.date.available2021-10-05T02:36:34Z-
dc.date.issued2021-
dc.identifier.citationmedRxiv: the Preprint for Health Sciences, 2021, June 23-
dc.identifier.urihttp://hdl.handle.net/10722/304882-
dc.descriptionHybrid open access-
dc.description.abstractHong Kong utilized an elimination strategy with intermittent use of public health and social measures and increasingly stringent travel regulations to control SARS-CoV-2 transmission. By analyzing >1700 genome sequences representing 17% of confirmed cases from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases, two of which circulated cryptically for weeks while less stringent measures were in place. We found that SARS-CoV-2 within-host diversity was most similar among transmission pairs and epidemiological clusters due to a strong transmission bottleneck through which similar genetic background generates similar within-host diversity.-
dc.languageeng-
dc.publisherCold Spring Harbor Laboratory. The Journal's web site is located at https://www.medrxiv.org/-
dc.relation.ispartofmedRxiv: the Preprint for Health Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSARS-CoV-2 under an elimination strategy in Hong Kong-
dc.typeArticle-
dc.identifier.emailGu, H: guhaogao@hku.hk-
dc.identifier.emailAdam, DC: dcadam@hku.hk-
dc.identifier.emailChang, LDJ: lydchang@hku.hk-
dc.identifier.emailCheuk, SSY: scheuk@HKUCC-COM.hku.hk-
dc.identifier.emailNg, DYM: daisy34@hku.hk-
dc.identifier.emailLiu, GYZ: gigilyz@hku.hk-
dc.identifier.emailEdwards, KM: kedwards@hku.hk-
dc.identifier.emailLeung, KSM: ksmleung@hku.hk-
dc.identifier.emailWu, JT: joewu@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.emailLam, TTY: ttylam@hku.hk-
dc.identifier.emailDhanasekaran, V: veej@hku.hk-
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hk-
dc.identifier.authorityChu, DK=rp02512-
dc.identifier.authorityLeung, KSM=rp02563-
dc.identifier.authorityWu, JT=rp00517-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityPeiris, M=rp00410-
dc.identifier.authorityLam, TTY=rp01733-
dc.identifier.authorityDhanasekaran, V=rp02721-
dc.identifier.authorityPoon, LLM=rp00484-
dc.description.naturepreprint-
dc.identifier.doi10.1101/2021.06.19.21259169-
dc.identifier.hkuros326013-
dc.identifier.volumeJune 23-
dc.identifier.spage44-
dc.identifier.epage44-
dc.publisher.placeUnited States-

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