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Book Chapter: An overview of potential therapeutic agents targeting Wnt/PCP signaling

TitleAn overview of potential therapeutic agents targeting Wnt/PCP signaling
Authors
KeywordsInhibitor
PCP
Planar cell polarity
WNT
WNT/PCP
Issue Date2021
PublisherSpringer International Publishing
Citation
An overview of potential therapeutic agents targeting Wnt/PCP signaling. In Schulte, G & Kozielewicz, P (Eds.), Pharmacology of the WNT Signaling System, p. 175-213. Cham: Springer International Publishing, 2021 How to Cite?
AbstractSince the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms. The canonical WNT signaling pathway depends on the stabilization and translocation of β-catenin and plays important roles in development and homeostasis. The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell behaviors. Similar to WNT/β-catenin signaling, disruption or aberrant activation of WNT/PCP signaling also underlies a variety of developmental defects and cancers. However, the pharmacological targeting of WNT/PCP signaling for therapeutic purposes remains largely unexplored. In this review, we briefly discuss WNT/PCP signaling in development and disease and summarize the known drugs/inhibitors targeting this pathway.
Persistent Identifierhttp://hdl.handle.net/10722/304906
ISBN

 

DC FieldValueLanguage
dc.contributor.authorWang, J-
dc.contributor.authorFeng, D-
dc.contributor.authorGao, B-
dc.date.accessioned2021-10-05T02:36:55Z-
dc.date.available2021-10-05T02:36:55Z-
dc.date.issued2021-
dc.identifier.citationAn overview of potential therapeutic agents targeting Wnt/PCP signaling. In Schulte, G & Kozielewicz, P (Eds.), Pharmacology of the WNT Signaling System, p. 175-213. Cham: Springer International Publishing, 2021-
dc.identifier.isbn9783030854980-
dc.identifier.urihttp://hdl.handle.net/10722/304906-
dc.description.abstractSince the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms. The canonical WNT signaling pathway depends on the stabilization and translocation of β-catenin and plays important roles in development and homeostasis. The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell behaviors. Similar to WNT/β-catenin signaling, disruption or aberrant activation of WNT/PCP signaling also underlies a variety of developmental defects and cancers. However, the pharmacological targeting of WNT/PCP signaling for therapeutic purposes remains largely unexplored. In this review, we briefly discuss WNT/PCP signaling in development and disease and summarize the known drugs/inhibitors targeting this pathway.-
dc.languageeng-
dc.publisherSpringer International Publishing-
dc.relation.ispartofPharmacology of the WNT Signaling System-
dc.subjectInhibitor-
dc.subjectPCP-
dc.subjectPlanar cell polarity-
dc.subjectWNT-
dc.subjectWNT/PCP-
dc.titleAn overview of potential therapeutic agents targeting Wnt/PCP signaling-
dc.typeBook_Chapter-
dc.identifier.emailFeng, D: fengdi90@hku.hk-
dc.identifier.emailGao, B: gaobo@hku.hk-
dc.identifier.authorityGao, B=rp02012-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/164_2021_533-
dc.identifier.scopuseid_2-s2.0-85118586843-
dc.identifier.hkuros326240-
dc.identifier.volume269-
dc.identifier.spage175-
dc.identifier.epage213-
dc.publisher.placeCham-

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