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- Publisher Website: 10.1007/164_2021_533
- Scopus: eid_2-s2.0-85118586843
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Book Chapter: An overview of potential therapeutic agents targeting Wnt/PCP signaling
Title | An overview of potential therapeutic agents targeting Wnt/PCP signaling |
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Authors | |
Keywords | Inhibitor PCP Planar cell polarity WNT WNT/PCP |
Issue Date | 2021 |
Publisher | Springer International Publishing |
Citation | An overview of potential therapeutic agents targeting Wnt/PCP signaling. In Schulte, G & Kozielewicz, P (Eds.), Pharmacology of the WNT Signaling System, p. 175-213. Cham: Springer International Publishing, 2021 How to Cite? |
Abstract | Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms. The canonical WNT signaling pathway depends on the stabilization and translocation of β-catenin and plays important roles in development and homeostasis. The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell behaviors. Similar to WNT/β-catenin signaling, disruption or aberrant activation of WNT/PCP signaling also underlies a variety of developmental defects and cancers. However, the pharmacological targeting of WNT/PCP signaling for therapeutic purposes remains largely unexplored. In this review, we briefly discuss WNT/PCP signaling in development and disease and summarize the known drugs/inhibitors targeting this pathway. |
Persistent Identifier | http://hdl.handle.net/10722/304906 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Wang, J | - |
dc.contributor.author | Feng, D | - |
dc.contributor.author | Gao, B | - |
dc.date.accessioned | 2021-10-05T02:36:55Z | - |
dc.date.available | 2021-10-05T02:36:55Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | An overview of potential therapeutic agents targeting Wnt/PCP signaling. In Schulte, G & Kozielewicz, P (Eds.), Pharmacology of the WNT Signaling System, p. 175-213. Cham: Springer International Publishing, 2021 | - |
dc.identifier.isbn | 9783030854980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304906 | - |
dc.description.abstract | Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms. The canonical WNT signaling pathway depends on the stabilization and translocation of β-catenin and plays important roles in development and homeostasis. The WNT/planar cell polarity (WNT/PCP) signaling, also known as one of the β-catenin-independent WNT pathways, conveys directional information to coordinate polarized cell behaviors. Similar to WNT/β-catenin signaling, disruption or aberrant activation of WNT/PCP signaling also underlies a variety of developmental defects and cancers. However, the pharmacological targeting of WNT/PCP signaling for therapeutic purposes remains largely unexplored. In this review, we briefly discuss WNT/PCP signaling in development and disease and summarize the known drugs/inhibitors targeting this pathway. | - |
dc.language | eng | - |
dc.publisher | Springer International Publishing | - |
dc.relation.ispartof | Pharmacology of the WNT Signaling System | - |
dc.subject | Inhibitor | - |
dc.subject | PCP | - |
dc.subject | Planar cell polarity | - |
dc.subject | WNT | - |
dc.subject | WNT/PCP | - |
dc.title | An overview of potential therapeutic agents targeting Wnt/PCP signaling | - |
dc.type | Book_Chapter | - |
dc.identifier.email | Feng, D: fengdi90@hku.hk | - |
dc.identifier.email | Gao, B: gaobo@hku.hk | - |
dc.identifier.authority | Gao, B=rp02012 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/164_2021_533 | - |
dc.identifier.scopus | eid_2-s2.0-85118586843 | - |
dc.identifier.hkuros | 326240 | - |
dc.identifier.volume | 269 | - |
dc.identifier.spage | 175 | - |
dc.identifier.epage | 213 | - |
dc.publisher.place | Cham | - |