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Article: Multiple‐Color Platinum Complex with Super‐Large Stokes Shift for Super‐Resolution Imaging of Autolysosome Escape

TitleMultiple‐Color Platinum Complex with Super‐Large Stokes Shift for Super‐Resolution Imaging of Autolysosome Escape
Authors
Issue Date2020
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773
Citation
Angewandte Chemie (International Edition), 2020, v. 59 n. 43, p. 19229-19236 How to Cite?
AbstractIt is of great significance to track the platinum drugs in real time with super-resolution to elucidate their mechanism of action, such as their behavior and distribution in live cells. Such information is required for further drug development. However, it is always challenging to design platinum complexes suitable for such research. Herein, we design a luminescent building block (L) for metal complexes and a dinuclear platinum complex (Pt2L) for super-resolution imaging. Because of its super-large Stokes shift and excellent photophysical properties, Pt2L is capable of serving as an ideal candidate for super-resolution imaging with extremely low luminescence background and high photobleaching resistance. Moreover, upon light stimulation, a matter flux of Pt2L escaping from autolysosomes to nucleus was observed, which represents a new transportation path. Utilizing the photoactivated escape properties, we can regulate the nuclear accessibility of Pt2L form autolysosomes with photo-selectivity, which provides a new way to improve the targeting of platinum drugs.
Persistent Identifierhttp://hdl.handle.net/10722/304936
ISSN
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, LY-
dc.contributor.authorFang, H-
dc.contributor.authorChen, Q-
dc.contributor.authorChan, MHY-
dc.contributor.authorNg, M-
dc.contributor.authorWang, KN-
dc.contributor.authorLiu, W-
dc.contributor.authorTian, Z-
dc.contributor.authorDiao, J-
dc.contributor.authorMao, ZW-
dc.contributor.authorYam, VWW-
dc.date.accessioned2021-10-05T02:37:22Z-
dc.date.available2021-10-05T02:37:22Z-
dc.date.issued2020-
dc.identifier.citationAngewandte Chemie (International Edition), 2020, v. 59 n. 43, p. 19229-19236-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/304936-
dc.description.abstractIt is of great significance to track the platinum drugs in real time with super-resolution to elucidate their mechanism of action, such as their behavior and distribution in live cells. Such information is required for further drug development. However, it is always challenging to design platinum complexes suitable for such research. Herein, we design a luminescent building block (L) for metal complexes and a dinuclear platinum complex (Pt2L) for super-resolution imaging. Because of its super-large Stokes shift and excellent photophysical properties, Pt2L is capable of serving as an ideal candidate for super-resolution imaging with extremely low luminescence background and high photobleaching resistance. Moreover, upon light stimulation, a matter flux of Pt2L escaping from autolysosomes to nucleus was observed, which represents a new transportation path. Utilizing the photoactivated escape properties, we can regulate the nuclear accessibility of Pt2L form autolysosomes with photo-selectivity, which provides a new way to improve the targeting of platinum drugs.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleMultiple‐Color Platinum Complex with Super‐Large Stokes Shift for Super‐Resolution Imaging of Autolysosome Escape-
dc.typeArticle-
dc.identifier.emailChan, MHY: mchanhy@hku.hk-
dc.identifier.emailYam, VWW: deanmail@hku.hk-
dc.identifier.authorityYam, VWW=rp00822-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.202007878-
dc.identifier.pmid32662563-
dc.identifier.scopuseid_2-s2.0-85089579567-
dc.identifier.hkuros326326-
dc.identifier.volume59-
dc.identifier.issue43-
dc.identifier.spage19229-
dc.identifier.epage19236-
dc.identifier.isiWOS:000561032800001-
dc.publisher.placeGermany-

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