File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Higher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors

TitleHigher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors
Authors
KeywordsCOVID-19
SARS-CoV-2
Thyroid function tests
Thyroid gland
Thyroiditis
Issue Date2021
PublisherSpringer. The Journal's web site is located at https://www.springer.com/journal/12020
Citation
Endocrine, 2021, Epub 2021-09-01 How to Cite?
Abstractme reverse transcription-polymerase chain reaction of the respiratory specimen on admission. Results: In total, 79 COVID-19 patients and 44 non-COVID-19 controls were included. All abnormal thyroid function tests during acute COVID-19 recovered upon follow-up. Thyroid ultrasonography was performed at a median of 67 days after acute COVID-19. The median thyroid volume was 9.73 mL (IQR: 7.87-13.70). In multivariable linear regression, SARS-CoV-2 VL on presentation (standardized beta -0.206, p = 0.042) inversely correlated with thyroid volume, in addition to body mass index at the time of ultrasonography (p < 0.001). Sex-specific analysis revealed similar results among men but not women. Eleven COVID-19 patients (13.9%) had ultrasonographic changes suggestive of thyroiditis, comparable to non-COVID-19 patients (p = 0.375). None of these 11 patients had isolated low thyroid-stimulating hormone levels suggestive of thyroiditis at initial admission or the time of ultrasonography. Conclusions: Higher SARS-CoV-2 VL on presentation were associated with smaller thyroid volumes, especially in men. Further research is suggested to investigate this possible direct viral effect of SARS-CoV-2 on the thyroid gland. There was no increased rate of ultrasonographic features suggestive of thyroiditis in COVID-19 survivors.
DescriptionBronze open access
Persistent Identifierhttp://hdl.handle.net/10722/304955
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.844
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, DTW-
dc.contributor.authorFung, MMH-
dc.contributor.authorChiu, WHK-
dc.contributor.authorLee, CH-
dc.contributor.authorChow, WS-
dc.contributor.authorLee, ACH-
dc.contributor.authorTam, AR-
dc.contributor.authorPang, P-
dc.contributor.authorHo, TY-
dc.contributor.authorFong, CHY-
dc.contributor.authorLoong, CHN-
dc.contributor.authorWong, WW-
dc.contributor.authorLee, CYY-
dc.contributor.authorLaw, CY-
dc.contributor.authorTo, KKW-
dc.contributor.authorLam, CW-
dc.contributor.authorTan, KCB-
dc.contributor.authorWoo, YC-
dc.contributor.authorHung, IFN-
dc.contributor.authorLam, KSL-
dc.contributor.authorLang, BHH-
dc.date.accessioned2021-10-05T02:37:38Z-
dc.date.available2021-10-05T02:37:38Z-
dc.date.issued2021-
dc.identifier.citationEndocrine, 2021, Epub 2021-09-01-
dc.identifier.issn1355-008X-
dc.identifier.urihttp://hdl.handle.net/10722/304955-
dc.descriptionBronze open access-
dc.description.abstractme reverse transcription-polymerase chain reaction of the respiratory specimen on admission. Results: In total, 79 COVID-19 patients and 44 non-COVID-19 controls were included. All abnormal thyroid function tests during acute COVID-19 recovered upon follow-up. Thyroid ultrasonography was performed at a median of 67 days after acute COVID-19. The median thyroid volume was 9.73 mL (IQR: 7.87-13.70). In multivariable linear regression, SARS-CoV-2 VL on presentation (standardized beta -0.206, p = 0.042) inversely correlated with thyroid volume, in addition to body mass index at the time of ultrasonography (p < 0.001). Sex-specific analysis revealed similar results among men but not women. Eleven COVID-19 patients (13.9%) had ultrasonographic changes suggestive of thyroiditis, comparable to non-COVID-19 patients (p = 0.375). None of these 11 patients had isolated low thyroid-stimulating hormone levels suggestive of thyroiditis at initial admission or the time of ultrasonography. Conclusions: Higher SARS-CoV-2 VL on presentation were associated with smaller thyroid volumes, especially in men. Further research is suggested to investigate this possible direct viral effect of SARS-CoV-2 on the thyroid gland. There was no increased rate of ultrasonographic features suggestive of thyroiditis in COVID-19 survivors.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at https://www.springer.com/journal/12020-
dc.relation.ispartofEndocrine-
dc.rightsAccepted Manuscript (AAM) This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectCOVID-19-
dc.subjectSARS-CoV-2-
dc.subjectThyroid function tests-
dc.subjectThyroid gland-
dc.subjectThyroiditis-
dc.titleHigher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors-
dc.typeArticle-
dc.identifier.emailLui, DTW: dtwlui@hku.hk-
dc.identifier.emailLee, CH: pchlee@hku.hk-
dc.identifier.emailChow, WS: chowws01@hkucc.hku.hk-
dc.identifier.emailPang, P: pollpang@hku.hk-
dc.identifier.emailHo, TY: tipyinho@hku.hk-
dc.identifier.emailFong, CHY: kalofong@hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hku.hk-
dc.identifier.emailLam, CW: ching-wanlam@pathology.hku.hk-
dc.identifier.emailWoo, YC: wooyucho@hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailLang, BHH: Blang@hku.hk-
dc.identifier.authorityLui, DTW=rp02803-
dc.identifier.authorityChiu, WHK=rp02074-
dc.identifier.authorityLee, CH=rp02043-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityLam, CW=rp00260-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityLang, BHH=rp01828-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s12020-021-02855-2-
dc.identifier.pmid34467467-
dc.identifier.pmcidPMC8408037-
dc.identifier.scopuseid_2-s2.0-85114003382-
dc.identifier.hkuros326287-
dc.identifier.volumeEpub 2021-09-01-
dc.identifier.isiWOS:000691713700001-
dc.publisher.placeGermany-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats