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Article: Enhanced Near‐Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite‐Based P–N Heterojunction

TitleEnhanced Near‐Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite‐Based P–N Heterojunction
Authors
Keywordscharge transfer
MRSA biofilm
osseointegration
photocatalytic
P–N heterojunction
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2021, v. 8 n. 15, p. article no. 2002211 How to Cite?
AbstractMethicillin-resistant Staphylococcus aureus (MRSA) biofilm infections after orthopedic implant increase the risk of failure and potentially cause amputation of limbs or life-threatening sepsis in severe cases. Additionally, satisfactory bone-implant integration is another important indicator of an ideal implant. Here, an antibiotic-free antibacterial nanofilm based on oxide perovskite-type calcium titanate (CTO)/fibrous red phosphorus (RP) on titanium implant surface (Ti-CTO/RP) in which the P–N heterojunction and internal electric field are established at the heterointerface, is designed. Near-infrared light-excited electron–hole pairs are effectively separated and transferred through the synergism of the internal electric field and band offset, which strongly boosts the photocatalytic eradication of MRSA biofilms by reactive oxygen species with an efficacy of 99.42% ± 0.22% in vivo. Additionally, the charge transfer endows the heterostructure with hyperthermia to assist biofilm eradication. Furthermore, CTO/RP nanofilm provides a superior biocompatible and osteoconductive platform that enables the proliferation and osteogenic differentiation of mesenchymal stem cells, thus contributing to the subsequent implant-to-bone osseointegration after eradicating MRSA biofilms.
Persistent Identifierhttp://hdl.handle.net/10722/305009
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 3.914
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMAO, C-
dc.contributor.authorZHU, W-
dc.contributor.authorXIANG, Y-
dc.contributor.authorZHU, Y-
dc.contributor.authorShen, J-
dc.contributor.authorLIU, X-
dc.contributor.authorWU, S-
dc.contributor.authorCheung, KMC-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2021-10-05T02:38:26Z-
dc.date.available2021-10-05T02:38:26Z-
dc.date.issued2021-
dc.identifier.citationAdvanced Science, 2021, v. 8 n. 15, p. article no. 2002211-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/305009-
dc.description.abstractMethicillin-resistant Staphylococcus aureus (MRSA) biofilm infections after orthopedic implant increase the risk of failure and potentially cause amputation of limbs or life-threatening sepsis in severe cases. Additionally, satisfactory bone-implant integration is another important indicator of an ideal implant. Here, an antibiotic-free antibacterial nanofilm based on oxide perovskite-type calcium titanate (CTO)/fibrous red phosphorus (RP) on titanium implant surface (Ti-CTO/RP) in which the P–N heterojunction and internal electric field are established at the heterointerface, is designed. Near-infrared light-excited electron–hole pairs are effectively separated and transferred through the synergism of the internal electric field and band offset, which strongly boosts the photocatalytic eradication of MRSA biofilms by reactive oxygen species with an efficacy of 99.42% ± 0.22% in vivo. Additionally, the charge transfer endows the heterostructure with hyperthermia to assist biofilm eradication. Furthermore, CTO/RP nanofilm provides a superior biocompatible and osteoconductive platform that enables the proliferation and osteogenic differentiation of mesenchymal stem cells, thus contributing to the subsequent implant-to-bone osseointegration after eradicating MRSA biofilms.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcharge transfer-
dc.subjectMRSA biofilm-
dc.subjectosseointegration-
dc.subjectphotocatalytic-
dc.subjectP–N heterojunction-
dc.titleEnhanced Near‐Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite‐Based P–N Heterojunction-
dc.typeArticle-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.202002211-
dc.identifier.pmid34145798-
dc.identifier.pmcidPMC8336500-
dc.identifier.scopuseid_2-s2.0-85108235591-
dc.identifier.hkuros326134-
dc.identifier.volume8-
dc.identifier.issue15-
dc.identifier.spagearticle no. 2002211-
dc.identifier.epagearticle no. 2002211-
dc.identifier.isiWOS:000663295800001-
dc.publisher.placeGermany-

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