File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Circulating tumor cells are an indicator for the administration of adjuvant transarterial chemoembolization in hepatocellular carcinoma: A single‐center, retrospective, propensity‐matched study

TitleCirculating tumor cells are an indicator for the administration of adjuvant transarterial chemoembolization in hepatocellular carcinoma: A single‐center, retrospective, propensity‐matched study
Authors
Keywordsa propensity score matching analysis
adjuvant transcatheter arterial chemoembolization
circulating tumor cells
hepatocellular carcinoma
Issue Date2020
PublisherWiley Open Access: Creative Commons Attribution License. The Journal's web site is located at http://www.clintransmed.com
Citation
Clinical and Translational Medicine, 2020, v. 10 n. 3, p. article no. e137 How to Cite?
AbstractBackground: High rates of postoperative tumor recurrence contribute to poor outcome in hepatocellular carcinoma (HCC). Here, we investigated whether circulating tumor cells (CTCs) status can predict the benefit of adjuvant transcatheter arterial chemoembolization (TACE) in patients with HCC. Methods: The retrospective study enrolled 344 HCC patients with preoperative CTCs analysis. Clinical outcomes including recurrence and survival were compared between those who received and who did not receive adjuvant TACE. Similar comparisons were made for patients stratified according to CTC status (CTC-negative [CTC = 0], n = 123; CTC-positive [CTC ≥ 1], n = 221). Propensity score matching (PSM) strategy was adopted to offset differences between two groups. Results: In the study cohort as a whole or in CTC-negative cohort, there were no observable differences in overall survival (OS) or time to recurrence (TTR) between TACE and control group (P > .05). In CTC-positive patients, PSM generated 64 patient pairs, and patients with adjuvant TACE had significantly better clinical outcomes (OS: not reached vs 36.4 months, P < .001; TTR: 45.8 vs 9.8 months, P < .001). Adjuvant TACE significantly reduced early recurrence (≤2 years) (64.1% vs 31.7%, P < .001) in CTC-positive patients. Notably, adjuvant TACE influenced TTR and OS even in subgroups of CTC-positive patients with low risk of recurrence according to traditional evaluation. Conclusions: Preoperative CTC status could serve as an indicator for the administration of adjuvant TACE in HCC patients. Adjuvant TACE benefits CTC-positive HCC patients mainly by reducing early recurrence.
Persistent Identifierhttp://hdl.handle.net/10722/305048
ISSN
2023 Impact Factor: 7.9
2023 SCImago Journal Rankings: 2.424
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, PX-
dc.contributor.authorSun, YF-
dc.contributor.authorZhou, KQ-
dc.contributor.authorCheng, JW-
dc.contributor.authorHu, B-
dc.contributor.authorGuo, W-
dc.contributor.authorYin, Y-
dc.contributor.authorHuang, JF-
dc.contributor.authorZhou, J-
dc.contributor.authorFan, J-
dc.contributor.authorCheung, TT-
dc.contributor.authorQu, XD-
dc.contributor.authorYang, XR-
dc.date.accessioned2021-10-05T02:39:00Z-
dc.date.available2021-10-05T02:39:00Z-
dc.date.issued2020-
dc.identifier.citationClinical and Translational Medicine, 2020, v. 10 n. 3, p. article no. e137-
dc.identifier.issn2001-1326-
dc.identifier.urihttp://hdl.handle.net/10722/305048-
dc.description.abstractBackground: High rates of postoperative tumor recurrence contribute to poor outcome in hepatocellular carcinoma (HCC). Here, we investigated whether circulating tumor cells (CTCs) status can predict the benefit of adjuvant transcatheter arterial chemoembolization (TACE) in patients with HCC. Methods: The retrospective study enrolled 344 HCC patients with preoperative CTCs analysis. Clinical outcomes including recurrence and survival were compared between those who received and who did not receive adjuvant TACE. Similar comparisons were made for patients stratified according to CTC status (CTC-negative [CTC = 0], n = 123; CTC-positive [CTC ≥ 1], n = 221). Propensity score matching (PSM) strategy was adopted to offset differences between two groups. Results: In the study cohort as a whole or in CTC-negative cohort, there were no observable differences in overall survival (OS) or time to recurrence (TTR) between TACE and control group (P > .05). In CTC-positive patients, PSM generated 64 patient pairs, and patients with adjuvant TACE had significantly better clinical outcomes (OS: not reached vs 36.4 months, P < .001; TTR: 45.8 vs 9.8 months, P < .001). Adjuvant TACE significantly reduced early recurrence (≤2 years) (64.1% vs 31.7%, P < .001) in CTC-positive patients. Notably, adjuvant TACE influenced TTR and OS even in subgroups of CTC-positive patients with low risk of recurrence according to traditional evaluation. Conclusions: Preoperative CTC status could serve as an indicator for the administration of adjuvant TACE in HCC patients. Adjuvant TACE benefits CTC-positive HCC patients mainly by reducing early recurrence.-
dc.languageeng-
dc.publisherWiley Open Access: Creative Commons Attribution License. The Journal's web site is located at http://www.clintransmed.com-
dc.relation.ispartofClinical and Translational Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjecta propensity score matching analysis-
dc.subjectadjuvant transcatheter arterial chemoembolization-
dc.subjectcirculating tumor cells-
dc.subjecthepatocellular carcinoma-
dc.titleCirculating tumor cells are an indicator for the administration of adjuvant transarterial chemoembolization in hepatocellular carcinoma: A single‐center, retrospective, propensity‐matched study-
dc.typeArticle-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/ctm2.137-
dc.identifier.pmid32702202-
dc.identifier.pmcidPMC7418815-
dc.identifier.hkuros326127-
dc.identifier.volume10-
dc.identifier.issue3-
dc.identifier.spagearticle no. e137-
dc.identifier.epagearticle no. e137-
dc.identifier.isiWOS:000551289900001-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats