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- Publisher Website: 10.1021/acs.orglett.1c01377
- Scopus: eid_2-s2.0-85108552859
- PMID: 34076445
- WOS: WOS:000664333200027
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Article: β-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells
Title | β-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells |
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Authors | |
Issue Date | 2021 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
Citation | Organic Letters, 2021, v. 23 n. 12, p. 4640-4644 How to Cite? |
Abstract | We designed β-difluoroalkylamine to capture RNAs and proteins with high tempospatial resolution via proximity labeling mediated by photoinduced singlet oxygen. The appended azide group allows for RNA biotinylation and downstream analysis through both SPAAC and CuAAC. In particular, the β-difluoroalkylazide motif enjoys an enhanced CuAAC reaction rate, thus preserving good RNA integrity. |
Persistent Identifier | http://hdl.handle.net/10722/305288 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.245 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LIANG, J | - |
dc.contributor.author | JIA, H | - |
dc.contributor.author | LI, L | - |
dc.contributor.author | Li, X | - |
dc.contributor.author | Li, Y | - |
dc.date.accessioned | 2021-10-20T10:07:18Z | - |
dc.date.available | 2021-10-20T10:07:18Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Organic Letters, 2021, v. 23 n. 12, p. 4640-4644 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305288 | - |
dc.description.abstract | We designed β-difluoroalkylamine to capture RNAs and proteins with high tempospatial resolution via proximity labeling mediated by photoinduced singlet oxygen. The appended azide group allows for RNA biotinylation and downstream analysis through both SPAAC and CuAAC. In particular, the β-difluoroalkylazide motif enjoys an enhanced CuAAC reaction rate, thus preserving good RNA integrity. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | - |
dc.relation.ispartof | Organic Letters | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.title | β-Difluoroalkylamine as a Motif for Singlet Oxygen-Mediated Proximity Labeling in Living Cells | - |
dc.type | Article | - |
dc.identifier.email | Li, Y: yingli0e@hku.hk | - |
dc.identifier.authority | Li, Y=rp02548 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.orglett.1c01377 | - |
dc.identifier.pmid | 34076445 | - |
dc.identifier.scopus | eid_2-s2.0-85108552859 | - |
dc.identifier.hkuros | 328373 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 4640 | - |
dc.identifier.epage | 4644 | - |
dc.identifier.isi | WOS:000664333200027 | - |
dc.publisher.place | United States | - |