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Article: A Magnetic Resonance-Guided Focused Ultrasound Neuromodulation System With a Whole Brain Coil Array for Nonhuman Primates at 3 T

TitleA Magnetic Resonance-Guided Focused Ultrasound Neuromodulation System With a Whole Brain Coil Array for Nonhuman Primates at 3 T
Authors
KeywordsMR-guided focused ultrasound
neuromodulation
nonhuman primates
phased-array coil
Issue Date2020
PublisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieee-tmi.org/
Citation
IEEE Transactions on Medical Imaging, 2020, v. 39 n. 12, p. 4401-4412 How to Cite?
AbstractThe phased-array radio frequency (RF) coil plays a vital role in magnetic resonance-guided focused ultrasound (MRgFUS) neuromodulation studies, where accurate brain functional stimulations and neural circuit observations are required. Although various designs of phased-array coils have been reported, few are suitable for ultrasound stimulations. In this study, an MRgFUS neuromodulation system comprised of a whole brain coverage non-human primate (NHP) RF coil and an MRI-compatible ultrasound device was developed. When compared to a single loop coil, the NHP coil provided up to a 50% increase in the signal-to-noise ratio (SNR) in the brain and acquired better anatomical image-quality. The NHP coil also demonstrated the ability to achieve higher spatial resolution and reduce distortion in echo-planer imaging (EPI). Ultrasound beam characteristics and transcranial magnetic resonance acoustic radiation force (MR-ARF) were measured for simulated positions, and calculated B0 maps were employed to establish MRI-compatibility. The differences between focused off and on ultrasound techniques were measured using SNR, g-factors, and temporal SNR (tSNR) analyses and all deviations were under 2.3%. The EPI images quality and stable tSNR demonstrated the suitability of the MRgFUS neuromodulation system to conduct functional MRI studies. Last, the time course of the blood oxygen level dependent (BOLD) signal of posterior cingulate cortex in a focused ultrasound neuromodulation study was detected and repeated with MR thermometry.
Persistent Identifierhttp://hdl.handle.net/10722/305313
ISSN
2023 Impact Factor: 8.9
2023 SCImago Journal Rankings: 3.703
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Y-
dc.contributor.authorLee, J-
dc.contributor.authorLong, X-
dc.contributor.authorQiao, Y-
dc.contributor.authorMa, T-
dc.contributor.authorHe, Q-
dc.contributor.authorCao, P-
dc.contributor.authorZhang, X-
dc.contributor.authorZheng, H-
dc.date.accessioned2021-10-20T10:07:39Z-
dc.date.available2021-10-20T10:07:39Z-
dc.date.issued2020-
dc.identifier.citationIEEE Transactions on Medical Imaging, 2020, v. 39 n. 12, p. 4401-4412-
dc.identifier.issn0278-0062-
dc.identifier.urihttp://hdl.handle.net/10722/305313-
dc.description.abstractThe phased-array radio frequency (RF) coil plays a vital role in magnetic resonance-guided focused ultrasound (MRgFUS) neuromodulation studies, where accurate brain functional stimulations and neural circuit observations are required. Although various designs of phased-array coils have been reported, few are suitable for ultrasound stimulations. In this study, an MRgFUS neuromodulation system comprised of a whole brain coverage non-human primate (NHP) RF coil and an MRI-compatible ultrasound device was developed. When compared to a single loop coil, the NHP coil provided up to a 50% increase in the signal-to-noise ratio (SNR) in the brain and acquired better anatomical image-quality. The NHP coil also demonstrated the ability to achieve higher spatial resolution and reduce distortion in echo-planer imaging (EPI). Ultrasound beam characteristics and transcranial magnetic resonance acoustic radiation force (MR-ARF) were measured for simulated positions, and calculated B0 maps were employed to establish MRI-compatibility. The differences between focused off and on ultrasound techniques were measured using SNR, g-factors, and temporal SNR (tSNR) analyses and all deviations were under 2.3%. The EPI images quality and stable tSNR demonstrated the suitability of the MRgFUS neuromodulation system to conduct functional MRI studies. Last, the time course of the blood oxygen level dependent (BOLD) signal of posterior cingulate cortex in a focused ultrasound neuromodulation study was detected and repeated with MR thermometry.-
dc.languageeng-
dc.publisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieee-tmi.org/-
dc.relation.ispartofIEEE Transactions on Medical Imaging-
dc.rightsIEEE Transactions on Medical Imaging. Copyright © Institute of Electrical and Electronics Engineers.-
dc.rights©20xx IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.-
dc.subjectMR-guided focused ultrasound-
dc.subjectneuromodulation-
dc.subjectnonhuman primates-
dc.subjectphased-array coil-
dc.titleA Magnetic Resonance-Guided Focused Ultrasound Neuromodulation System With a Whole Brain Coil Array for Nonhuman Primates at 3 T-
dc.typeArticle-
dc.identifier.emailCao, P: caopeng1@hku.hk-
dc.identifier.authorityCao, P=rp02474-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1109/TMI.2020.3019087-
dc.identifier.scopuseid_2-s2.0-85092701993-
dc.identifier.hkuros326789-
dc.identifier.volume39-
dc.identifier.issue12-
dc.identifier.spage4401-
dc.identifier.epage4412-
dc.identifier.isiWOS:000595547500057-
dc.publisher.placeUnited States-

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