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Article: Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications

TitleIntercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications
Authors
KeywordsAdipose tissue browning
Circulating factors
Energy homeostasis
Adipose biology
Obesity
Issue Date2021
PublisherOxford University Press. The Journal's web site is located at http://jmcb.oxfordjournals.org/
Citation
Journal of Molecular Cell Biology, 2021, v. 13 n. 7, p. 466-479 How to Cite?
AbstractAdipose tissue (AT) is highly plastic and heterogeneous in response to environmental and nutritional changes. The development of heat-dissipating beige adipocytes in white AT (WAT) through a process known as browning (or beiging) has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic complications. This is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic health. WAT consists of adipocytes, nerves, vascular endothelial cells, various types of immune cells, adipocyte progenitor cells, and fibroblasts. These cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning capacity. In addition, inter-organ crosstalk is also important for beige adipocyte biogenesis. Here, we summarize recent findings on fat depot-specific differences, secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes, as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.
Persistent Identifierhttp://hdl.handle.net/10722/305392
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 1.506
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheong, LY-
dc.contributor.authorXu, A-
dc.date.accessioned2021-10-20T10:08:45Z-
dc.date.available2021-10-20T10:08:45Z-
dc.date.issued2021-
dc.identifier.citationJournal of Molecular Cell Biology, 2021, v. 13 n. 7, p. 466-479-
dc.identifier.issn1674-2788-
dc.identifier.urihttp://hdl.handle.net/10722/305392-
dc.description.abstractAdipose tissue (AT) is highly plastic and heterogeneous in response to environmental and nutritional changes. The development of heat-dissipating beige adipocytes in white AT (WAT) through a process known as browning (or beiging) has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic complications. This is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic health. WAT consists of adipocytes, nerves, vascular endothelial cells, various types of immune cells, adipocyte progenitor cells, and fibroblasts. These cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning capacity. In addition, inter-organ crosstalk is also important for beige adipocyte biogenesis. Here, we summarize recent findings on fat depot-specific differences, secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes, as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jmcb.oxfordjournals.org/-
dc.relation.ispartofJournal of Molecular Cell Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdipose tissue browning-
dc.subjectCirculating factors-
dc.subjectEnergy homeostasis-
dc.subjectAdipose biology-
dc.subjectObesity-
dc.titleIntercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications-
dc.typeArticle-
dc.identifier.emailCheong, LY: u3003285@connect.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/jmcb/mjab038-
dc.identifier.pmid34185049-
dc.identifier.pmcidPMC8530522-
dc.identifier.scopuseid_2-s2.0-85119504951-
dc.identifier.hkuros328004-
dc.identifier.volume13-
dc.identifier.issue7-
dc.identifier.spage466-
dc.identifier.epage479-
dc.identifier.isiWOS:000715359100002-
dc.publisher.placeUnited Kingdom-

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