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Article: Frequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth‐onset type 2 diabetes: Results from a nationwide, multicentre, clinic‐based, cross‐sectional study (LADA China)

TitleFrequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth‐onset type 2 diabetes: Results from a nationwide, multicentre, clinic‐based, cross‐sectional study (LADA China)
Authors
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DOM
Citation
Diabetes, Obesity and Metabolism, 2021, v. 23 n. 6, p. 1282-1291 How to Cite?
AbstractAim: To investigate the frequency, clinical phenotype, inflammatory cytokine levels and genetics of glutamic acid decarboxylase autoantibody (GADA)-positive phenotypic youth-onset type 2 diabetes. Materials and Methods: This nationwide, multicentre, cross-sectional study included 5324 newly diagnosed subjects with phenotypic type 2 diabetes aged 15 years or older enrolled in the LADA China study. GADA was screened in 248 subjects with youth-onset type 2 diabetes aged 15–29 years. Subjects who presented as GADA-positive were defined as having latent autoimmune diabetes in youth (LADY). We added subjects with LADY, type 1 diabetes, type 2 diabetes and controls from the Diabetes Center of Central South University, and measured serum concentrations of interleukin-6, lipocalin 2, high-sensitivity C-reactive protein, adiponectin and human leukocyte antigen (HLA) genotyping in subjects with LADY, age- and sex-matched GADA-negative type 2 diabetes, type 1 diabetes and controls. Results: Twenty-nine of the 248 subjects (11.7%) were GADA positive. Compared with subjects with type 2 diabetes, subjects with LADY were less probable to have metabolic syndrome (27.6% vs. 59.4%; p = .001). The fasting C-peptide levels tended to be lower in subjects with LADY than in subjects with type 2 diabetes, but the difference was not statistically significant (LADY vs. type 2 diabetes: 0.21 [0.17–0.64] vs. 0.47 [0.29–0.77] nmol/L; p = .11). The cytokine levels of subjects with LADY were indistinguishable from subjects with type 1 diabetes, but subjects with LADY presented increased adiponectin levels compared with subjects with type 2 diabetes after adjusting for age, sex and body mass index (7.19 [4.05–11.66] vs. 3.42 [2.35–5.74] μg/mL; p < .05). The frequency of total susceptible HLA genotypes (DR3/3, −3/9 and −9/9) in subjects with LADY and type 1 diabetes were similarly higher than controls (LADY and type 1 diabetes vs. controls: 21.4% and 30.8% vs. 2.6%, respectively; p < .001). Conclusions: A high GADA positivity was observed in youth-onset type 2 diabetes subjects in China. As subjects with LADY had an increased susceptible HLA genetic load and different cytokine levels compared with subjects with type 2 diabetes, differentiating LADY from phenotypic type 2 diabetes subjects is important.
Persistent Identifierhttp://hdl.handle.net/10722/305393
ISSN
2023 Impact Factor: 5.4
2023 SCImago Journal Rankings: 2.079
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiang, Y-
dc.contributor.authorLiu, B-
dc.contributor.authorYun, C-
dc.contributor.authorZhou, P-
dc.contributor.authorLi, X-
dc.contributor.authorLuo, S-
dc.contributor.authorXie, Z-
dc.contributor.authorChe, Z-
dc.contributor.authorLin, J-
dc.contributor.authorYang, L-
dc.contributor.authorLi, X-
dc.contributor.authorHuang, G-
dc.contributor.authorXu, A-
dc.contributor.authorZhou, Z-
dc.date.accessioned2021-10-20T10:08:46Z-
dc.date.available2021-10-20T10:08:46Z-
dc.date.issued2021-
dc.identifier.citationDiabetes, Obesity and Metabolism, 2021, v. 23 n. 6, p. 1282-1291-
dc.identifier.issn1462-8902-
dc.identifier.urihttp://hdl.handle.net/10722/305393-
dc.description.abstractAim: To investigate the frequency, clinical phenotype, inflammatory cytokine levels and genetics of glutamic acid decarboxylase autoantibody (GADA)-positive phenotypic youth-onset type 2 diabetes. Materials and Methods: This nationwide, multicentre, cross-sectional study included 5324 newly diagnosed subjects with phenotypic type 2 diabetes aged 15 years or older enrolled in the LADA China study. GADA was screened in 248 subjects with youth-onset type 2 diabetes aged 15–29 years. Subjects who presented as GADA-positive were defined as having latent autoimmune diabetes in youth (LADY). We added subjects with LADY, type 1 diabetes, type 2 diabetes and controls from the Diabetes Center of Central South University, and measured serum concentrations of interleukin-6, lipocalin 2, high-sensitivity C-reactive protein, adiponectin and human leukocyte antigen (HLA) genotyping in subjects with LADY, age- and sex-matched GADA-negative type 2 diabetes, type 1 diabetes and controls. Results: Twenty-nine of the 248 subjects (11.7%) were GADA positive. Compared with subjects with type 2 diabetes, subjects with LADY were less probable to have metabolic syndrome (27.6% vs. 59.4%; p = .001). The fasting C-peptide levels tended to be lower in subjects with LADY than in subjects with type 2 diabetes, but the difference was not statistically significant (LADY vs. type 2 diabetes: 0.21 [0.17–0.64] vs. 0.47 [0.29–0.77] nmol/L; p = .11). The cytokine levels of subjects with LADY were indistinguishable from subjects with type 1 diabetes, but subjects with LADY presented increased adiponectin levels compared with subjects with type 2 diabetes after adjusting for age, sex and body mass index (7.19 [4.05–11.66] vs. 3.42 [2.35–5.74] μg/mL; p < .05). The frequency of total susceptible HLA genotypes (DR3/3, −3/9 and −9/9) in subjects with LADY and type 1 diabetes were similarly higher than controls (LADY and type 1 diabetes vs. controls: 21.4% and 30.8% vs. 2.6%, respectively; p < .001). Conclusions: A high GADA positivity was observed in youth-onset type 2 diabetes subjects in China. As subjects with LADY had an increased susceptible HLA genetic load and different cytokine levels compared with subjects with type 2 diabetes, differentiating LADY from phenotypic type 2 diabetes subjects is important.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DOM-
dc.relation.ispartofDiabetes, Obesity and Metabolism-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleFrequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth‐onset type 2 diabetes: Results from a nationwide, multicentre, clinic‐based, cross‐sectional study (LADA China)-
dc.typeArticle-
dc.identifier.emailZhou, P: zhoupc@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/dom.14336-
dc.identifier.pmid33528883-
dc.identifier.scopuseid_2-s2.0-85103268632-
dc.identifier.hkuros328017-
dc.identifier.volume23-
dc.identifier.issue6-
dc.identifier.spage1282-
dc.identifier.epage1291-
dc.identifier.isiWOS:000631529900001-
dc.publisher.placeUnited Kingdom-

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