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Article: A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss

TitleA GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss
Authors
KeywordsBone Biology
Depression
Neuroscience
Osteoporosis
Issue Date2020
PublisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org
Citation
Journal of Clinical Investigation, 2020, v. 130 n. 12, p. 6539-6554 How to Cite?
AbstractHomeostasis of bone metabolism is regulated by the central nervous system, and mood disorders such as anxiety are associated with bone metabolism abnormalities, yet our understanding of the central neural circuits regulating bone metabolism is limited. Here, we demonstrate that chronic stress in crewmembers resulted in decreased bone density and elevated anxiety in an isolated habitat mimicking a space station. We then used a mouse model to demonstrate that GABAergic neural circuitry in the ventromedial hypothalamus (VMH) mediates chronic stress–induced bone loss. We show that GABAergic inputs in the dorsomedial VMH arise from a specific group of somatostatin neurons in the posterior region of the bed nucleus of the stria terminalis, which is indispensable for stress-induced bone loss and is able to trigger bone loss in the absence of stressors. In addition, the sympathetic system and glutamatergic neurons in the nucleus tractus solitarius were employed to regulate stress-induced bone loss. Our study has therefore identified the central neural mechanism by which chronic stress–induced mood disorders, such as anxiety, influence bone metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/305403
ISSN
2021 Impact Factor: 19.456
2020 SCImago Journal Rankings: 6.278
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYANG, F-
dc.contributor.authorLIU, Y-
dc.contributor.authorCHEN, S-
dc.contributor.authorDAI, Z-
dc.contributor.authorYANG, D-
dc.contributor.authorGAO, D-
dc.contributor.authorSHAO, J-
dc.contributor.authorWANG, Y-
dc.contributor.authorWANG, T-
dc.contributor.authorZHANG, Z-
dc.contributor.authorZHANG, L-
dc.contributor.authorLu, WW-
dc.contributor.authorLI, Y-
dc.contributor.authorWANG, L-
dc.date.accessioned2021-10-20T10:08:55Z-
dc.date.available2021-10-20T10:08:55Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Investigation, 2020, v. 130 n. 12, p. 6539-6554-
dc.identifier.issn0021-9738-
dc.identifier.urihttp://hdl.handle.net/10722/305403-
dc.description.abstractHomeostasis of bone metabolism is regulated by the central nervous system, and mood disorders such as anxiety are associated with bone metabolism abnormalities, yet our understanding of the central neural circuits regulating bone metabolism is limited. Here, we demonstrate that chronic stress in crewmembers resulted in decreased bone density and elevated anxiety in an isolated habitat mimicking a space station. We then used a mouse model to demonstrate that GABAergic neural circuitry in the ventromedial hypothalamus (VMH) mediates chronic stress–induced bone loss. We show that GABAergic inputs in the dorsomedial VMH arise from a specific group of somatostatin neurons in the posterior region of the bed nucleus of the stria terminalis, which is indispensable for stress-induced bone loss and is able to trigger bone loss in the absence of stressors. In addition, the sympathetic system and glutamatergic neurons in the nucleus tractus solitarius were employed to regulate stress-induced bone loss. Our study has therefore identified the central neural mechanism by which chronic stress–induced mood disorders, such as anxiety, influence bone metabolism.-
dc.languageeng-
dc.publisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org-
dc.relation.ispartofJournal of Clinical Investigation-
dc.subjectBone Biology-
dc.subjectDepression-
dc.subjectNeuroscience-
dc.subjectOsteoporosis-
dc.titleA GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss-
dc.typeArticle-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.authorityLu, WW=rp00411-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1172/JCI136105-
dc.identifier.pmid32910804-
dc.identifier.pmcidPMC7685749-
dc.identifier.scopuseid_2-s2.0-85097113462-
dc.identifier.hkuros327518-
dc.identifier.volume130-
dc.identifier.issue12-
dc.identifier.spage6539-
dc.identifier.epage6554-
dc.identifier.isiWOS:000600420500002-
dc.publisher.placeUnited States-

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