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Article: A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma

TitleA comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 5189 How to Cite?
AbstractUsing Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12–37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/305443
ISSN
2020 Impact Factor: 14.919
2020 SCImago Journal Rankings: 5.559
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, X-
dc.contributor.authorCao, SM-
dc.contributor.authorCai, YL-
dc.contributor.authorZhang, X-
dc.contributor.authorZhang, S-
dc.contributor.authorFeng, GF-
dc.contributor.authorChen, Y-
dc.contributor.authorFeng, QS-
dc.contributor.authorChen, Y-
dc.contributor.authorChang, ET-
dc.contributor.authorLiu, Z-
dc.contributor.authorAdami, HO-
dc.contributor.authorLiu, J-
dc.contributor.authorYe, W-
dc.contributor.authorZhang, Z-
dc.contributor.authorZeng, YX-
dc.contributor.authorXu, M-
dc.date.accessioned2021-10-20T10:09:28Z-
dc.date.available2021-10-20T10:09:28Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 5189-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/305443-
dc.description.abstractUsing Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12–37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailLiu, Z: zhhliu@hku.hk-
dc.identifier.authorityLiu, Z=rp02429-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-25402-z-
dc.identifier.pmid34465768-
dc.identifier.pmcidPMC8408241-
dc.identifier.scopuseid_2-s2.0-85114192257-
dc.identifier.hkuros327198-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 5189-
dc.identifier.epagearticle no. 5189-
dc.identifier.isiWOS:000692406300001-
dc.publisher.placeUnited Kingdom-

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