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Article: Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses

TitleRisk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses
Authors
KeywordsChina
HPAI H5Nx
Hong Kong
alveolar epithelial cells
clade 2.3.4.4
Issue Date2021
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2021, v. 27 n. 10, p. 2619-2627 How to Cite?
AbstractThe numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. They showed differential cellular tropism in human airway organoids; some infected all 4 major epithelial cell types: ciliated cells, club cells, goblet cells, and basal cells. Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. These viruses induced low levels of proinflammatory cytokines/chemokines, which are unlikely to contribute to the pathogenesis of severe disease.
Persistent Identifierhttp://hdl.handle.net/10722/305700
ISSN
2020 Impact Factor: 6.883
2020 SCImago Journal Rankings: 2.540
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBui, CHT-
dc.contributor.authorKuok, DIT-
dc.contributor.authorYeung, HW-
dc.contributor.authorNg, KC-
dc.contributor.authorChu, DKW-
dc.contributor.authorWebby, RJ-
dc.contributor.authorNicholls, JM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorHui, KPY-
dc.contributor.authorChan, MCW-
dc.date.accessioned2021-10-20T10:13:04Z-
dc.date.available2021-10-20T10:13:04Z-
dc.date.issued2021-
dc.identifier.citationEmerging Infectious Diseases, 2021, v. 27 n. 10, p. 2619-2627-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/305700-
dc.description.abstractThe numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. They showed differential cellular tropism in human airway organoids; some infected all 4 major epithelial cell types: ciliated cells, club cells, goblet cells, and basal cells. Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. These viruses induced low levels of proinflammatory cytokines/chemokines, which are unlikely to contribute to the pathogenesis of severe disease.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChina-
dc.subjectHPAI H5Nx-
dc.subjectHong Kong-
dc.subjectalveolar epithelial cells-
dc.subjectclade 2.3.4.4-
dc.titleRisk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses-
dc.typeArticle-
dc.identifier.emailBui, CHT: clyyee@hku.hk-
dc.identifier.emailYeung, HW: hinwo@hku.hk-
dc.identifier.emailNg, KC: kckachun@hku.hk-
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailHui, KPY: kenrie@hku.hk-
dc.identifier.emailChan, MCW: mchan@hku.hk-
dc.identifier.authorityChu, DKW=rp02512-
dc.identifier.authorityNicholls, JM=rp00364-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityHui, KPY=rp02149-
dc.identifier.authorityChan, MCW=rp00420-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2710.210297-
dc.identifier.pmid34545790-
dc.identifier.pmcidPMC8462306-
dc.identifier.scopuseid_2-s2.0-85115431319-
dc.identifier.hkuros327833-
dc.identifier.volume27-
dc.identifier.issue10-
dc.identifier.spage2619-
dc.identifier.epage2627-
dc.identifier.isiWOS:000710239500013-
dc.publisher.placeUnited States-

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