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- Publisher Website: 10.1096/fj.202100757R
- Scopus: eid_2-s2.0-85115831220
- PMID: 34569087
- WOS: WOS:000702238200061
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Article: Target‐specific control of piriform cortical output via distinct inhibitory circuits
Title | Target‐specific control of piriform cortical output via distinct inhibitory circuits |
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Authors | |
Issue Date | 2021 |
Publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ |
Citation | The FASEB Journal, 2021, v. 35 n. 10, p. article no. e21944 How to Cite? |
Abstract | Information represented by principal neurons in anterior piriform cortex (APC) is regulated by local, recurrent excitation and inhibition, but the circuit mechanisms remain elusive. Two types of layer 2 (L2) principal neurons, semilunar (SL), and superficial pyramidal (SP) cells, are parallel output channels, and the control of their activity gates the output of APC. Here, we examined the hypothesis that recurrent inhibition differentially regulates SL and SP cells. Patterned optogenetic stimulation revealed that the strength of recurrent inhibition is target- and layer-specific: L1 > L3 for SL cells, but L3 > L1 for SP cells. This target- and layer-specific inhibition was largely attributable to the parvalbumin (PV), but not somatostatin, interneurons. Intriguingly, olfactory experience selectively modulated the PV to SP microcircuit while maintaining the overall target and laminar specificity of inhibition. Together, these results indicate the importance of target-specific inhibitory wiring for odor processing, implicating these mechanisms in gating the output of piriform cortex. |
Description | Hybrid open access |
Persistent Identifier | http://hdl.handle.net/10722/305730 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jiang, HH | - |
dc.contributor.author | Go, A | - |
dc.contributor.author | Chiu, A | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Lai, CSW | - |
dc.contributor.author | Lau, CG | - |
dc.date.accessioned | 2021-10-20T10:13:31Z | - |
dc.date.available | 2021-10-20T10:13:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | The FASEB Journal, 2021, v. 35 n. 10, p. article no. e21944 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305730 | - |
dc.description | Hybrid open access | - |
dc.description.abstract | Information represented by principal neurons in anterior piriform cortex (APC) is regulated by local, recurrent excitation and inhibition, but the circuit mechanisms remain elusive. Two types of layer 2 (L2) principal neurons, semilunar (SL), and superficial pyramidal (SP) cells, are parallel output channels, and the control of their activity gates the output of APC. Here, we examined the hypothesis that recurrent inhibition differentially regulates SL and SP cells. Patterned optogenetic stimulation revealed that the strength of recurrent inhibition is target- and layer-specific: L1 > L3 for SL cells, but L3 > L1 for SP cells. This target- and layer-specific inhibition was largely attributable to the parvalbumin (PV), but not somatostatin, interneurons. Intriguingly, olfactory experience selectively modulated the PV to SP microcircuit while maintaining the overall target and laminar specificity of inhibition. Together, these results indicate the importance of target-specific inhibitory wiring for odor processing, implicating these mechanisms in gating the output of piriform cortex. | - |
dc.language | eng | - |
dc.publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ | - |
dc.relation.ispartof | The FASEB Journal | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Target‐specific control of piriform cortical output via distinct inhibitory circuits | - |
dc.type | Article | - |
dc.identifier.email | Lai, CSW: coraswl@hku.hk | - |
dc.identifier.authority | Lai, CSW=rp01895 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1096/fj.202100757R | - |
dc.identifier.pmid | 34569087 | - |
dc.identifier.scopus | eid_2-s2.0-85115831220 | - |
dc.identifier.hkuros | 327204 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | article no. e21944 | - |
dc.identifier.epage | article no. e21944 | - |
dc.identifier.isi | WOS:000702238200061 | - |
dc.publisher.place | United States | - |