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Article: Photo-triggered nucleus targeting for cancer drug delivery

TitlePhoto-triggered nucleus targeting for cancer drug delivery
Authors
LI, YLyu, WWANG, LZHANG, YYang, LWANG, TZhu, LWang, YWang, W
Keywordsphototargeting
dePEGylation
nucleus targeting
coumarin
photoresponsive prodrugs
Issue Date2021
PublisherTsinghua University Press, co-published with Springer Verlag. The Journal's web site is located at http://www.springer.com/materials/nanotechnology/journal/12274
Citation
Nano Research, 2021, v. 14, p. 2630-2636 How to Cite?
DOI: http://dx.doi.org/10.1007/s12274-020-3264-0
AbstractHere, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control. The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs. By incorporating a nucleus localization sequence in the system, drug nanoparticles could be delivered into nuclei upon visible light irradiation. The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability, which efficiently killed cancer cells. This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.
Persistent Identifierhttp://hdl.handle.net/10722/305762
ISSN
1998-0124
2021 Impact Factor: 10.269
2020 SCImago Journal Rankings: 2.536
ISI Accession Number ID
WOS:000604558500001

 

DC FieldValueLanguage
dc.contributor.authorLI, Y-
dc.contributor.authorLyu, W-
dc.contributor.authorWANG, L-
dc.contributor.authorZHANG, Y-
dc.contributor.authorYang, L-
dc.contributor.authorWANG, T-
dc.contributor.authorZhu, L-
dc.contributor.authorWang, Y-
dc.contributor.authorWang, W-
dc.date.accessioned2021-10-20T10:13:58Z-
dc.date.available2021-10-20T10:13:58Z-
dc.date.issued2021-
dc.identifier.citationNano Research, 2021, v. 14, p. 2630-2636-
dc.identifier.issn1998-0124-
dc.identifier.urihttp://hdl.handle.net/10722/305762-
dc.description.abstractHere, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control. The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs. By incorporating a nucleus localization sequence in the system, drug nanoparticles could be delivered into nuclei upon visible light irradiation. The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability, which efficiently killed cancer cells. This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.-
dc.languageeng-
dc.publisherTsinghua University Press, co-published with Springer Verlag. The Journal's web site is located at http://www.springer.com/materials/nanotechnology/journal/12274-
dc.relation.ispartofNano Research-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectphototargeting-
dc.subjectdePEGylation-
dc.subjectnucleus targeting-
dc.subjectcoumarin-
dc.subjectphotoresponsive prodrugs-
dc.titlePhoto-triggered nucleus targeting for cancer drug delivery-
dc.typeArticle-
dc.identifier.emailWang, Y: wanglab@hku.hk-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, Y=rp02191-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12274-020-3264-0-
dc.identifier.scopuseid_2-s2.0-85098546741-
dc.identifier.hkuros327370-
dc.identifier.volume14-
dc.identifier.spage2630-
dc.identifier.epage2636-
dc.identifier.isiWOS:000604558500001-
dc.publisher.placeChina-

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