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- Publisher Website: 10.3389/fimmu.2021.608680
- Scopus: eid_2-s2.0-85102461153
- PMID: 33717092
- WOS: WOS:000627128100001
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Article: Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases
Title | Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases |
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Authors | |
Keywords | exosome microRNA adipose tissue macrophage metabolic homeostasis inflammation |
Issue Date | 2021 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology |
Citation | Frontiers in Immunology, 2021, v. 12, p. article no. 608680 How to Cite? |
Abstract | Adipose tissue (AT) is a highly heterogeneous and dynamic organ that plays important roles in regulating energy metabolism and insulin sensitivity. In addition to its classical roles in nutrient sensing and energy storage/dissipation, AT secretes a large number of bioactive molecules (termed adipokines) participating in immune responses and metabolic regulation through their paracrine and/or endocrine actions. Adipose-derived extracellular vesicles (ADEVs), including exosomes, microvesicles (MVs), and apoptotic bodies, have recently emerged as a novel class of signal messengers, mediating intercellular communications and inter-organ crosstalk. In AT, ADEVs derived from adipocytes, immune cells, mesenchymal stem cells, endothelial cells are actively involved in modulation of immune microenvironment, adipogenesis, browing of white adipose tissue, adipokine release and tissue remodeling. Furthermore, ADEVs exert their metabolic actions in distal organs (such as liver, skeletal muscle, pancreas and brain) by sending genetic information (mainly in the form of microRNAs) to their target cells for regulation of gene expression. Here, we provide an updated summary on the nature and composition of ADEVs, and their pathophysiological functions in regulating immune responses, whole-body insulin sensitivity and metabolism. Furthermore, we highlight the latest clinical evidence supporting aberrant production and/or function of ADEVs as a contributor to obesity-related chronic inflammation and metabolic complications and discuss the opportunities and challenges in developing novel therapies by targeting ADEVs. |
Persistent Identifier | http://hdl.handle.net/10722/305852 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.868 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, Z | - |
dc.contributor.author | Xu, A | - |
dc.date.accessioned | 2021-10-20T10:15:15Z | - |
dc.date.available | 2021-10-20T10:15:15Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Frontiers in Immunology, 2021, v. 12, p. article no. 608680 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10722/305852 | - |
dc.description.abstract | Adipose tissue (AT) is a highly heterogeneous and dynamic organ that plays important roles in regulating energy metabolism and insulin sensitivity. In addition to its classical roles in nutrient sensing and energy storage/dissipation, AT secretes a large number of bioactive molecules (termed adipokines) participating in immune responses and metabolic regulation through their paracrine and/or endocrine actions. Adipose-derived extracellular vesicles (ADEVs), including exosomes, microvesicles (MVs), and apoptotic bodies, have recently emerged as a novel class of signal messengers, mediating intercellular communications and inter-organ crosstalk. In AT, ADEVs derived from adipocytes, immune cells, mesenchymal stem cells, endothelial cells are actively involved in modulation of immune microenvironment, adipogenesis, browing of white adipose tissue, adipokine release and tissue remodeling. Furthermore, ADEVs exert their metabolic actions in distal organs (such as liver, skeletal muscle, pancreas and brain) by sending genetic information (mainly in the form of microRNAs) to their target cells for regulation of gene expression. Here, we provide an updated summary on the nature and composition of ADEVs, and their pathophysiological functions in regulating immune responses, whole-body insulin sensitivity and metabolism. Furthermore, we highlight the latest clinical evidence supporting aberrant production and/or function of ADEVs as a contributor to obesity-related chronic inflammation and metabolic complications and discuss the opportunities and challenges in developing novel therapies by targeting ADEVs. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology | - |
dc.relation.ispartof | Frontiers in Immunology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | exosome | - |
dc.subject | microRNA | - |
dc.subject | adipose tissue macrophage | - |
dc.subject | metabolic homeostasis | - |
dc.subject | inflammation | - |
dc.title | Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases | - |
dc.type | Article | - |
dc.identifier.email | Huang, Z: huangzhe@connect.hku.hk | - |
dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | - |
dc.identifier.authority | Xu, A=rp00485 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fimmu.2021.608680 | - |
dc.identifier.pmid | 33717092 | - |
dc.identifier.scopus | eid_2-s2.0-85102461153 | - |
dc.identifier.hkuros | 328014 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | article no. 608680 | - |
dc.identifier.epage | article no. 608680 | - |
dc.identifier.isi | WOS:000627128100001 | - |
dc.publisher.place | Switzerland | - |